[Nerve distribution and density in the canine hip joint capsule. Comparison of healthy and dysplastic hip joints].

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  • Author(s): Giebels F;Giebels F; Prescher A; Wagenpfeil S; Bücker A; Kinzel S
  • Source:
    Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere [Tierarztl Prax Ausg K Kleintiere Heimtiere] 2017 Apr 19; Vol. 45 (2), pp. 77-83. Date of Electronic Publication: 2017 Feb 15.
  • Publication Type:
    Journal Article
  • Language:
    German
  • Additional Information
    • Transliterated Title:
      Nervenverteilung und -verteilungsdichte in der Hüftgelenkskapsel des Hundes. Vergleichende Untersuchung gesunder und dysplastischer Hüftgelenke.
    • Source:
      Publisher: Thieme Country of Publication: Germany NLM ID: 9717383 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2567-5842 (Electronic) Linking ISSN: 14341239 NLM ISO Abbreviation: Tierarztl Prax Ausg K Kleintiere Heimtiere Subsets: MEDLINE
    • Publication Information:
      Publication: 2018- : Stuttgart : Thieme
      Original Publication: Stuttgart : F.K. Schattauer Verlagsgesellschaft
    • Subject Terms:
      Dogs/*anatomy & histology ; Hip Dysplasia, Canine/*pathology ; Hip Joint/*innervation ; Joint Capsule/*innervation; Animals ; Case-Control Studies ; Hip Joint/physiology ; Hip Joint/physiopathology ; Joint Capsule/physiology ; Joint Capsule/physiopathology
    • Abstract:
      Objective: The hip-joint capsule is exposed to increased tension forces during canine hip dysplasia, resulting in inflammation of the capsular tissue. It has been postulated that inflammation is associated with an increased nerve-distribution density. Therefore, it could be supposed that the nerve-distribution density in the hip-joint capsule is higher in dogs with dysplastic hip compared to healthy dogs.
      Material and Methods: In 16 Labrador Retriever dogs that had been euthanised due to unrelated reasons, the hip joints were classified as normoplastic (group 1, n = 18) or dysplastic (group 2, n = 14) based on radiography. Following staining of the capsular nerve fibres by the Sihler method, histological specimens of the hip-joint capsules were scanned. By subdividing each specimen into 10 quadrants numbered from dorsomedial (Q01) to craniodorsolateral (Q10), the ratio of black to white pixels was calculated digitally for each specimen and each quadrant by using a semiautomatic image analysis. Statistical analysis was performed using an independent t-test.
      Results: Comparison of the mean values of each quadrant showed a significantly higher (p < 0.03) nerve distribution density for the craniodorsolateral quadrant (Q10) in group 2 when compared to group 1. Mean nerve-distribution density for all quadrants combined was not significantly different between the two groups.
      Conclusion: The increase in nerve-distribution density of the craniodorsal region of the hip-joint capsule in dogs with dysplastic hip could be the result of increased tension forces on this area following hip-joint dysplasia. The craniodorsal region of the hip-joint capsule is an important origin of pain and coxarthrosis in canine hip dysplasia.
      Clinical Relevance: The results provide the pathophysiological basis for the efficacy of hip-joint denervation. Denervation of the cranial region of the acetabular rim is essential to reduce capsular inflammation and joint-related pain in canine hip dysplasia.
    • Contributed Indexing:
      Keywords: Neurogenic inflammation; capsular stretch; coxarthrosis; denervation
    • Publication Date:
      Date Created: 20170216 Date Completed: 20170620 Latest Revision: 20170620
    • Publication Date:
      20221213
    • Accession Number:
      10.15654/TPK-160366
    • Accession Number:
      28197624