[Change of white matter neuronal integrity associated with spatial navigation impairment in mild cognitive impairment].

Publisher: Zhonghua yi xue hui Country of Publication: China NLM ID: 7511141 Publication Model: Print Cited Medium: Print ISSN: 0376-2491 (Print) Linking ISSN: 03762491 NLM ISO Abbreviation: Zhonghua Yi Xue Za Zhi Subsets: MEDLINE

Publication: Beijing : Zhonghua yi xue hui
Original Publication: Beijing : Zhonghua yi xue hui.

Spatial Navigation*; Cognitive Dysfunction/*pathology ; White Matter/*pathology; Anisotropy ; Brain ; Case-Control Studies ; Cognitive Dysfunction/physiopathology ; Diffusion Tensor Imaging ; Humans

Objective: To analyze the correlation between white matter integrity and spatial navigation impairment in patients with mild cognitive impairment (MCI). Methods: A total of 27 MCI subjects and 24 healthy controls were enrolled from the Affiliated Drum Tower Hospital of Nanjing University Medical School from May 2015 to February 2016, who underwent 3.0 T MRI scan and 2D-computer version spatial navigation test.DTI preprocessing and tract-based spatial statistics (TBSS) were performed by PANDA.Two sample t -test and partial correlation coefficients were performed to investigate the correlation of white matter impairments and spatial navigation decline. Results: Relative to controls, MCI showed worse egocentric navigation ( t =-2.202, P <0.05). Decreased FA in superior longitudinal fasciculus (left t =2.95, right t =2.95, P <0.05), inferior longitudinal fasciculus and inferior fronto-occipital fasciculus (left t =2.66, right t =2.96, P <0.05), corpus callosum ( t =2.09, P <0.05), cingulum (left t =2.76, right t =2.41, P <0.05), fornix ( t =4.83, P <0.05), and corticospinal tract (left t =2.33, right t =2.26, P <0.05), were found in the MCI subjects.The decreased FA value of superior longitudinal fasciculus (left r =-0.354, right r =-0.347, P <0.05), inferior longitudinal fasciculus (left r =-0.338, right r =-0.336, P <0.05), cingulum (left r =-0.395, right r =-0.370, P <0.05), right corticospinal tract ( r =-0.362, P <0.05) and fornix ( r =-0.369, P <0.05) were correlated with increased ego average total error.Allo average total error were negative correlated with FA value of superior longitudinal fasciculus (left r =-0.329, right r =-0.350, P <0.05), inferior longitudinal fasciculus (left r =-0.349, right r =-0.378, P <0.05), splenium of corpus callosum ( r =-0.364, P <0.05) and cingulum (left r =-0.340, right r =-0.406, P <0.05). Conclusion: This study implicated the potential white matter structural basis of spatial navigation impairment and will have an impact on the further study of the neurobiological mechanisms of human spatial navigation ability.

Keywords: Cognition disorders; Perceptual disorders; Spatial navigation
Local Abstract: [Publisher, Chinese] 目的： 采用基于纤维束空间统计分析方法探索轻度认知障碍(MCI)患者空间导航障碍相关脑白质微观结构的改变。 方法： 选取2015年5月至2016年2月在南京大学医学院附属鼓楼医院神经内科就诊的27例MCI患者和年龄、性别、受教育程度匹配的24名正常认知健康对照组(NC)进行空间导航能力测试及3.0 T磁共振扫描，采用PANDA软件对扩散张量成像(DTI)数据进行预处理后对被试的部分各向异性(FA)图进行全脑非参数统计学比较及相关性分析。 结果： MCI组自我导航能力显著低于健康对照组( t ＝－2.202， P <0.05)，FA值减低的纤维束主要位于双侧上纵束(左侧 t ＝2.95，右侧 t ＝2.95， P <0.05)、双侧下纵束及额枕下束(左侧 t ＝2.66，右侧 t ＝2.96， P <0.05)，胼胝体束( t ＝2.09， P <0.05)及扣带束(左侧 t ＝2.76，右侧 t ＝2.41， P <0.05)，穹窿( t ＝4.83， P <0.05)，双侧皮质脊髓束(左侧 t ＝2.33，右侧 t ＝2.26， P <0.05)。其中，双侧上纵束(左侧 r ＝－0.354，右侧 r ＝－0.347， P <0.05)、双侧下纵束(左侧 r ＝－0.338，右侧 r ＝－0.336， P <0.05)、扣带束(左侧 r ＝－0.395，右侧 r ＝－0.370， P <0.05)及右侧皮质脊髓束( r ＝－0.362， P <0.05)、穹隆束( r ＝－0.369， P <0.05)的FA值与自我导航平均误差距离呈显著负相关。双侧上纵束(左侧 r ＝－0.329，右侧 r ＝－0.350， P <0.05)、双侧下纵束(左侧 r ＝－0.349，右侧 r ＝－0.378， P <0.05)、胼胝体束压部( r ＝－0.364， P <0.05)及扣带束(左侧 r ＝－0.340，右侧 r ＝－0.406， P <0.05)的FA值与环境导航平均误差距离呈显著负相关。 结论： 脑白质微观结构改变是MCI患者空间导航能力减退的病理基础，对进一步研究影响人类空间导航能力的潜在神经生物学机制有重要价值。.

Date Created: 20170207 Date Completed: 20180625 Latest Revision: 20181202

20221213

10.3760/cma.j.issn.0376-2491.2017.03.005

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