Myc inhibits JNK-mediated cell death in vivo.

Publisher: Springer Country of Publication: Netherlands NLM ID: 9712129 Publication Model: Print Cited Medium: Internet ISSN: 1573-675X (Electronic) Linking ISSN: 13608185 NLM ISO Abbreviation: Apoptosis Subsets: MEDLINE

Publication: 2005- : Dordrecht, Netherlands : Springer
Original Publication: London : Rapid Science Publishers,

Genes, myc*; Apoptosis/*genetics ; DNA-Binding Proteins/*physiology ; Drosophila Proteins/*physiology ; Drosophila melanogaster/*genetics ; MAP Kinase Signaling System/*genetics ; Transcription Factors/*physiology; Animals ; Compound Eye, Arthropod/cytology ; Compound Eye, Arthropod/embryology ; Compound Eye, Arthropod/growth & development ; DNA-Binding Proteins/deficiency ; DNA-Binding Proteins/genetics ; Drosophila Proteins/deficiency ; Drosophila Proteins/genetics ; Drosophila melanogaster/cytology ; Female ; Gene Expression Regulation, Developmental ; Genes, Synthetic ; Humans ; Larva ; Membrane Proteins/genetics ; Membrane Proteins/physiology ; Morphogenesis ; Protein Isoforms/genetics ; Protein Isoforms/physiology ; Proto-Oncogene Mas ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/physiology ; Recombinant Fusion Proteins/metabolism ; Species Specificity ; Thorax/cytology ; Thorax/embryology ; Thorax/growth & development ; Transcription Factors/deficiency ; Transcription Factors/genetics ; Wings, Animal/cytology ; Wings, Animal/embryology ; Wings, Animal/growth & development

The proto-oncogene Myc is well known for its roles in promoting cell growth, proliferation and apoptosis. However, in this study, we found from a genetic screen that Myc inhibits, rather than promotes, cell death triggered by c-Jun N-terminal kinase (JNK) signaling in Drosophila. Firstly, expression of Drosophila Myc (dMyc) suppresses, whereas loss of dMyc enhances, ectopically activated JNK signaling-induced cell death. Secondly, dMyc impedes physiologically activated JNK pathway-mediated cell death. Thirdly, loss of dMyc triggers JNK pathway activation and JNK-dependent cell death. Finally, the mammalian cMyc gene, when expressed in Drosophila, impedes activated JNK signaling-induced cell death. Thus, besides its well-studied apoptosis promoting function, Myc also antagonizes JNK-mediated cell death in Drosophila, and this function is likely conserved from fly to human.

Keywords: Cell death; Drosophila; JNK pathway; Myc

0 (DNA-Binding Proteins)
0 (Drosophila Proteins)
0 (GAL4 protein, Drosophila)
0 (MAS1 protein, human)
0 (MYC protein, human)
0 (Membrane Proteins)
0 (Myc protein, Drosophila)
0 (Protein Isoforms)
0 (Proto-Oncogene Mas)
0 (Proto-Oncogene Proteins c-myc)
0 (Recombinant Fusion Proteins)
0 (Transcription Factors)
0 (egr protein, Drosophila)

Date Created: 20170203 Date Completed: 20180306 Latest Revision: 20211204

20221213

10.1007/s10495-016-1340-4

28150056