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Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice.
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- Additional Information
- Source:
Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Print ISSN: 0036-8075 (Print) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
- Publication Information:
Publication: : Washington, DC : American Association for the Advancement of Science
Original Publication: New York, N.Y. : [s.n.] 1880-
- Subject Terms:
- Abstract:
When rodents are infected with the nematode Nippostrongylus brasiliensis, large numbers of eosinophils appear in their blood and lungs and their serum immunoglobulin E (IgE) is increased. Injection of a monoclonal antibody to interleukin-5 completely suppressed the blood eosinophilia and the infiltration of eosinophils in the lungs of parasitized mice but had no effect on serum IgE. In contrast, an antibody to interleukin-4 inhibited parasite-induced IgE but not the eosinophilia. These results show that interleukin-5 is important in eosinophil production in vivo and that IgE and eosinophil production are regulated by different cytokines produced by the TH2 subset of CD4-expressing T cells.
- Accession Number:
0 (Antibodies, Monoclonal)
0 (Interleukin-5)
0 (Interleukins)
207137-56-2 (Interleukin-4)
37341-29-0 (Immunoglobulin E)
- Publication Date:
Date Created: 19890721 Date Completed: 19890818 Latest Revision: 20190618
- Publication Date:
20221208
- Accession Number:
10.1126/science.2787531
- Accession Number:
2787531
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