Neurochemical and behavioral effects of Nigella sativa and Olea europaea oil in rats.

Publisher: Taylor & Francis Country of Publication: England NLM ID: 100892202 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-8305 (Electronic) Linking ISSN: 1028415X NLM ISO Abbreviation: Nutr Neurosci Subsets: MEDLINE

Publication: 2016- : Abingdon : Taylor & Francis
Original Publication: [Amsterdam?] : Harwood Academic Publishers : Overseas Publishers Association [distributor], c1998-

Dietary Supplements*/adverse effects ; Learning* ; Memory*; Nigella sativa/*chemistry ; Nootropic Agents/*therapeutic use ; Olea/*chemistry ; Plant Oils/*administration & dosage; Animals ; Anti-Anxiety Agents/administration & dosage ; Anti-Anxiety Agents/adverse effects ; Anti-Anxiety Agents/therapeutic use ; Anxiety/prevention & control ; Behavior, Animal ; Brain/metabolism ; Dopamine Agonists/administration & dosage ; Dopamine Agonists/adverse effects ; Dopamine Agonists/therapeutic use ; Ethnopharmacology ; Homovanillic Acid/agonists ; Homovanillic Acid/metabolism ; Male ; Maze Learning ; Medicine, Traditional ; Neurons/metabolism ; Nootropic Agents/administration & dosage ; Nootropic Agents/adverse effects ; Pakistan ; Plant Oils/adverse effects ; Plant Oils/therapeutic use ; Random Allocation ; Rats, Wistar ; Serotonin Receptor Agonists/administration & dosage ; Serotonin Receptor Agonists/adverse effects ; Serotonin Receptor Agonists/therapeutic use

Objectives: In the last few decades, therapeutic uses of medicinal compounds present in food as a normal constituent has risen substantially, largely because of their fewer side effects and adequate efficacy. This study is designed to investigate a role of brain serotonin (5-HT) and dopamine (DA) in the potential nootropic, anxiolytic, and other beneficial effects of Nigella sativa (NS) and Olea europaea (OE) oil in rat models.
Methods: Animals were treated with NS and OE oil orally at doses of 0.1 ml/kg and 0.25 ml/kg for 5 weeks. Food intake and body weight change, anxiety-like effects in elevated plus maze and activity in a novel and familiar environment were monitored weekly. Effects on learning and memory after 5 weeks treatment were monitored using Morris water maze test. Neurochemical analysis was carried using HPLC-ECD method.
Results: NS and OE oil administration enhanced learning and memory in Morris water maze test and the effects were greater in NS than OE oil-treated animals. Low dose of OE oil increased exploration in an open field, higher dose of OE oil and both doses of NS oil produced no consistent effect on open field exploration. Effects of both oils on anxiety-like behavior, food and water intake, and activity in activity box were either not consistent or did not occur. The treatment increased homovanillic acid (HVA). 5-HT levels increased in high dose of NS oil and low dose of OE oil-treated groups. Low dose NS oil decreased 5-HT.
Discussion: The present study suggests that active components in NS and OE oil may prove useful in treating impaired cognition. OE oil may produce psychostimulant-like effect. Modulation of DA and serotonin neurotransmission seems important in the pharmacological effect of these oils.

Keywords: Anxiety; Dopamine; Learning; Memory; Motor activity; Nigella sativa; Olea europaea; Serotonin

0 (Anti-Anxiety Agents)
0 (Dopamine Agonists)
0 (Nootropic Agents)
0 (Plant Oils)
0 (Serotonin Receptor Agonists)
C2J9B08Q3I (caraway oil)
X77S6GMS36 (Homovanillic Acid)

Date Created: 20161122 Date Completed: 20180823 Latest Revision: 20180823

20240829

10.1080/1028415X.2016.1257417

27868798