Preformulation of cysteamine gels for treatment of the ophthalmic complications in cystinosis.

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  • Additional Information
    • Source:
      Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
    • Subject Terms:
      Cornea/*drug effects ; Cysteamine/*chemistry ; Cysteamine/*pharmacology ; Eye Diseases/*drug therapy ; Gels/*chemistry ; Gels/*pharmacology; Acrylic Resins/chemistry ; Animals ; Cattle ; Cellulose/analogs & derivatives ; Cellulose/chemistry ; Chemistry, Pharmaceutical/methods ; Cystinosis/complications ; Drug Delivery Systems/methods ; Eye Diseases/etiology ; Humans ; Hyaluronic Acid/chemistry ; Ophthalmic Solutions/chemistry ; Ophthalmic Solutions/pharmacology ; Polymers/chemistry ; Rheology ; Solubility
    • Abstract:
      Nephropathic cystinosis is a rare autosomal recessive disease characterised by raised lysosomal levels of cystine in the cells of all organs. It is treated by regular administration of the aminothiol, cysteamine. Corneal crystal deposition is one of the most troublesome complications affecting patients and requires the hourly administration of cysteamine eye drops. In an attempt to reduce this frequency and improve the treatment, the preformulation and evaluation of cysteamine containing gels is reported. Suitability for ophthalmic delivery was determined by analysis of rheology, bioadhesion, dissolution and stability. The results demonstrated that three polymers were suitable for ophthalmic delivery of cysteamine; namely sodium hyaluronate, hydroxyethyl cellulose and carbomer 934. Sodium hyaluronate displayed optimum performance in the preformulation tests, being pseudoplastic (reduction in apparent viscosity under increasing shear rate), bioadhesive, releasing cysteamine over 40min and displaying stability over time. In conclusion these results offer the possibility to formulate cysteamine in an ocular applicable gel formulation.
      (Copyright © 2016 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Cysteamine; Cystinosis; Gel; Ophthalmic delivery; Preformulation
    • Accession Number:
      0 (Acrylic Resins)
      0 (Gels)
      0 (Ophthalmic Solutions)
      0 (Polymers)
      4Q93RCW27E (carbopol 940)
      5UX2SD1KE2 (Cysteamine)
      9004-34-6 (Cellulose)
      9004-61-9 (Hyaluronic Acid)
      9004-62-0 (hydroxyethylcellulose)
    • Publication Date:
      Date Created: 20161106 Date Completed: 20170417 Latest Revision: 20170828
    • Publication Date:
      20250114
    • Accession Number:
      10.1016/j.ijpharm.2016.10.044
    • Accession Number:
      27771488