Levels of metabolic markers in drug-naive prediabetic and type 2 diabetic patients.

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  • Additional Information
    • Source:
      Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9200299 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-5233 (Electronic) Linking ISSN: 09405429 NLM ISO Abbreviation: Acta Diabetol Subsets: MEDLINE
    • Publication Information:
      Publication: Berlin : Springer Verlag
      Original Publication: Berlin : Springer International, c1991-
    • Subject Terms:
      Diabetes Mellitus, Type 2/*blood ; Prediabetic State/*blood; Adult ; Biomarkers/blood ; Case-Control Studies ; Cytokines/blood ; Female ; Fibroblast Growth Factors/blood ; Fibronectins/blood ; GPI-Linked Proteins/blood ; Humans ; Lectins/blood ; Male ; Middle Aged
    • Abstract:
      Aims: Type 2 diabetes mellitus (T2DM) and prediabetes (pre-DM) are associated with changes in levels of metabolic markers. The main aim of this study is to compare the levels of omentin, irisin, endothelin-1, nesfatin, hepatocyte growth factor (HGF), fibroblast growth factor, and oxytocin (OXT) between normoglycemic and pre-DM/T2DM obese Jordanian patients.
      Methods: One hundred and ninety-eight adult Jordanian subjects were recruited. Demographic data and clinical parameters were collected. The serum levels of biomarkers were measured by enzymatic assay procedure.
      Results: Compared to normoglycemic (95 subjects), pre-DM/T2DM (103 subjects) displayed higher HGF (ng/ml) = 78.8 (71.4-104) versus 55.9 (45.3-66.6), p < 0.0001; and nesfatin (ng/ml) = 0.5 (0.4-0.7) versus 0.2 (0.1-0.4), p < 0.0001; betatrophin (ng/ml) = 1.2 (0.8-1.6) versus 0.22 (0.15-0.41), p < 0.0001. On the other hand, they had lower levels of omentin (ng/ml) = 2.1 (0.9-3.3) versus 3.6 (2.0-6.4), p < 0.0001, irisin (ng/ml) = 113.7 (88.9-142.9) versus 132.6 (110.7-147.8), p < 0.0001; and oxytocin (pg/ml) = 1077.9 (667.3-1506.0) versus 2180.1 (1464.5-2795.6), p < 0.0001; respectively. In comparison, FGF-21 (ng/ml) = 0.3 (0.2-0.5) versus 0.2 (0.1-0.4), and endothelin (pg/ml) = 2.7 (1.3-5.2) versus 2.8 (1.6-5.6) did not differ between the two groups (p > 0.05).
      Conclusions: In the present study, patients with pre-DM and T2DM have higher serum levels of metabolic HGF, nesfatin, and betatrophin and lower levels of omentin, irisin, and OXT. Future longitudinal and interventional studies are required to confirm the utility of these markers as novel progression or therapeutic targets in the pharmacotherapy of diabetes.
    • Contributed Indexing:
      Keywords: Oxytocin; Prediabetes; Type 2 diabetes mellitus
    • Accession Number:
      0 (Biomarkers)
      0 (Cytokines)
      0 (Fibronectins)
      0 (GPI-Linked Proteins)
      0 (ITLN1 protein, human)
      0 (Lectins)
      0 (fibroblast growth factor 21)
      62031-54-3 (Fibroblast Growth Factors)
    • Publication Date:
      Date Created: 20161019 Date Completed: 20170227 Latest Revision: 20220409
    • Publication Date:
      20231215
    • Accession Number:
      10.1007/s00592-016-0926-1
    • Accession Number:
      27752839