Interferon-dependent immunoproteasome activity during mouse adenovirus type 1 infection.

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  • Additional Information
    • Source:
      Publisher: Academic Press Country of Publication: United States NLM ID: 0110674 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0341 (Electronic) Linking ISSN: 00426822 NLM ISO Abbreviation: Virology Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York, Academic Press.
    • Subject Terms:
      Immunomodulation*/genetics ; Immunomodulation*/immunology; Adenoviridae/*physiology ; Adenoviridae Infections/*immunology ; Adenoviridae Infections/*metabolism ; Interferons/*metabolism ; Proteasome Endopeptidase Complex/*metabolism; Adenoviridae Infections/mortality ; Adenoviridae Infections/virology ; Animals ; Integrin beta Chains/genetics ; Integrin beta Chains/metabolism ; Interferon-gamma/genetics ; Interferon-gamma/metabolism ; Interferons/genetics ; Mice ; Mice, Knockout ; Myocarditis/genetics ; Myocarditis/immunology ; Myocarditis/metabolism ; Myocarditis/virology ; Proteasome Endopeptidase Complex/genetics
    • Abstract:
      The immunoproteasome is an inducible host mechanism that aids in the clearance of damaged proteins. The immunoproteasome also influences immune function by enhancing peptide presentation by MHC class I and promotes inflammation via IκB degradation and activation of NF-κB. We used mouse adenovirus type 1 (MAV-1) to characterize the role of the immunoproteasome in adenovirus pathogenesis. Following intranasal infection of mice, immunoproteasome activity in the heart and lung was significantly increased in an IFN-γ-dependent manner. Absence of the β5i immunoproteasome subunit and pharmacological inhibition of β5i activity had minimal effects on viral replication, virus-induced cellular inflammation, or induction of cytokine expression. Likewise, the establishment of protective immunity following primary infection was not significantly altered by β5i deficiency. Thus, although immunoproteasome activity is robustly induced during acute infection with MAV-1, our data suggest that other mechanisms are capable of compensating for immunoproteasome activity to maintain antiviral immunity and appropriate inflammatory responses.
      (Copyright © 2016 Elsevier Inc. All rights reserved.)
    • References:
      Cell Mol Life Sci. 2012 Aug;69(15):2543-58. (PMID: 22382925)
      Eur Heart J. 2008 Sep;29(17):2073-82. (PMID: 18617482)
      J Immunol. 2006 Dec 1;177(11):7680-8. (PMID: 17114438)
      Virology. 2007 Jan 5;357(1):54-67. (PMID: 16962154)
      Am J Cardiovasc Dis. 2014 Jan 15;4(1):6-13. (PMID: 24551480)
      Circulation. 1994 Jul;90(1):330-9. (PMID: 8026015)
      Methods Mol Biol. 2014;1172:147-62. (PMID: 24908302)
      J Virol. 2011 Oct;85(20):10806-13. (PMID: 21835790)
      J Immunol. 2011 Dec 1;187(11):5548-57. (PMID: 22013127)
      Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9241-6. (PMID: 15944226)
      FASEB J. 2011 Mar;25(3):883-93. (PMID: 21098724)
      J Virol. 2003 Sep;77(18):10060-70. (PMID: 12941916)
      Clin Immunol Immunopathol. 1996 Sep;80(3 Pt 2):S92-9. (PMID: 8811068)
      Mol Biol Rep. 1995;21(1):21-6. (PMID: 7565659)
      Am J Pathol. 2006 May;168(5):1542-52. (PMID: 16651621)
      J Virol. 1988 Nov;62(11):3947-57. (PMID: 3172335)
      J Am Coll Cardiol. 2003 Aug 6;42(3):466-72. (PMID: 12906974)
      Virology. 1996 Oct 1;224(1):184-97. (PMID: 8862413)
      Cell. 1994 Sep 9;78(5):761-71. (PMID: 8087844)
      Nat Med. 2009 Jul;15(7):781-7. (PMID: 19525961)
      J Virol. 2015 Jan;89(1):468-79. (PMID: 25320326)
      Can J Cardiol. 1996 Oct;12(10):935-43. (PMID: 9191484)
      Virology. 2011 Dec 20;421(2):149-58. (PMID: 22018786)
      J Virol. 2005 Mar;79(6):3267-76. (PMID: 15731221)
      J Biol Chem. 1992 May 25;267(15):10515-23. (PMID: 1587832)
      J Biol Chem. 2003 Jan 3;278(1):139-46. (PMID: 12407112)
      PLoS One. 2011 Feb 03;6(2):e14646. (PMID: 21304910)
      J Exp Med. 1998 Jan 5;187(1):97-104. (PMID: 9419215)
      J Virol. 2011 Jan;85(1):146-55. (PMID: 20980503)
      Circulation. 2005 Sep 27;112(13):1965-70. (PMID: 16172268)
      Immunol Today. 1996 Sep;17(9):429-35. (PMID: 8854562)
      Virology. 2005 Sep 30;340(2):245-54. (PMID: 16054189)
      Virology. 2009 Aug 15;391(1):25-32. (PMID: 19564030)
      Virology. 2014 May;456-457:259-67. (PMID: 24889245)
      Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):8970-5. (PMID: 9256419)
      J Immunol. 2010 Apr 15;184(8):4115-22. (PMID: 20228196)
      Nucleic Acids Res. 2010 Jan;38(Database issue):D792-9. (PMID: 19906719)
      Front Microbiol. 2015 Jan 29;6:21. (PMID: 25688236)
      PLoS Pathog. 2011 Sep;7(9):e1002233. (PMID: 21909276)
      J Immunol. 2010 Nov 1;185(9):5549-60. (PMID: 20881186)
      Am J Pathol. 2009 Aug;175(2):510-8. (PMID: 19590042)
      Sci Rep. 2015 May 19;5:10230. (PMID: 25989070)
      J Biol Chem. 1997 May 16;272(20):13437-45. (PMID: 9148969)
      Virus Res. 2016 Mar 2;214:26-32. (PMID: 26795547)
      Nat Immunol. 2011 Dec 25;13(2):129-35. (PMID: 22197977)
      J Virol. 2012 Apr;86(8):4194-203. (PMID: 22345470)
      J Biol Chem. 1992 Nov 5;267(31):22369-77. (PMID: 1429590)
      PLoS One. 2015 Sep 25;10(9):e0139235. (PMID: 26407316)
      J Immunol. 2013 Jul 1;191(1):52-9. (PMID: 23709680)
      PLoS One. 2013 Oct 16;8(10):e77628. (PMID: 24147040)
      J Immunol. 2002 Sep 15;169(6):3046-52. (PMID: 12218120)
      Cell Biochem Biophys. 2011 Jun;60(1-2):119-26. (PMID: 21455681)
      Methods Mol Med. 2007;130:41-59. (PMID: 17401163)
      Pathol Oncol Res. 2011 Jun;17(2):229-35. (PMID: 20853075)
      J Virol. 1998 Feb;72(2):1219-23. (PMID: 9445021)
      J Immunol. 2001 Dec 15;167(12):6859-68. (PMID: 11739503)
      J Exp Med. 2001 Jun 4;193(11):1319-26. (PMID: 11390439)
      Circulation. 1999 Mar 16;99(10):1348-54. (PMID: 10077520)
    • Grant Information:
      R01 HL068936 United States HL NHLBI NIH HHS; R21 AI103452 United States AI NIAID NIH HHS; T32 AI007528 United States AI NIAID NIH HHS
    • Contributed Indexing:
      Keywords: Adenovirus; Immunoproteasome; Inflammation; Interferon gamma; Myocarditis; Respiratory infection
    • Accession Number:
      0 (Integrin beta Chains)
      0 (integrin beta5)
      82115-62-6 (Interferon-gamma)
      9008-11-1 (Interferons)
      EC 3.4.25.1 (LMP7 protein)
      EC 3.4.25.1 (Proteasome Endopeptidase Complex)
    • Publication Date:
      Date Created: 20160826 Date Completed: 20170504 Latest Revision: 20181113
    • Publication Date:
      20221213
    • Accession Number:
      PMC5045817
    • Accession Number:
      10.1016/j.virol.2016.08.009
    • Accession Number:
      27560373