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Interferon-dependent immunoproteasome activity during mouse adenovirus type 1 infection.
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- Author(s): McCarthy MK;McCarthy MK; Malitz DH; Malitz DH; Molloy CT; Molloy CT; Procario MC; Procario MC; Greiner KE; Greiner KE; Zhang L; Zhang L; Wang P; Wang P; Day SM; Day SM; Powell SR; Powell SR; Weinberg JB; Weinberg JB; Weinberg JB
- Source:
Virology [Virology] 2016 Nov; Vol. 498, pp. 57-68. Date of Electronic Publication: 2016 Aug 22.- Publication Type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Academic Press Country of Publication: United States NLM ID: 0110674 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0341 (Electronic) Linking ISSN: 00426822 NLM ISO Abbreviation: Virology Subsets: MEDLINE
- Publication Information: Original Publication: New York, Academic Press.
- Subject Terms: Immunomodulation*/genetics ; Immunomodulation*/immunology; Adenoviridae/*physiology ; Adenoviridae Infections/*immunology ; Adenoviridae Infections/*metabolism ; Interferons/*metabolism ; Proteasome Endopeptidase Complex/*metabolism; Adenoviridae Infections/mortality ; Adenoviridae Infections/virology ; Animals ; Integrin beta Chains/genetics ; Integrin beta Chains/metabolism ; Interferon-gamma/genetics ; Interferon-gamma/metabolism ; Interferons/genetics ; Mice ; Mice, Knockout ; Myocarditis/genetics ; Myocarditis/immunology ; Myocarditis/metabolism ; Myocarditis/virology ; Proteasome Endopeptidase Complex/genetics
- Abstract: The immunoproteasome is an inducible host mechanism that aids in the clearance of damaged proteins. The immunoproteasome also influences immune function by enhancing peptide presentation by MHC class I and promotes inflammation via IκB degradation and activation of NF-κB. We used mouse adenovirus type 1 (MAV-1) to characterize the role of the immunoproteasome in adenovirus pathogenesis. Following intranasal infection of mice, immunoproteasome activity in the heart and lung was significantly increased in an IFN-γ-dependent manner. Absence of the β5i immunoproteasome subunit and pharmacological inhibition of β5i activity had minimal effects on viral replication, virus-induced cellular inflammation, or induction of cytokine expression. Likewise, the establishment of protective immunity following primary infection was not significantly altered by β5i deficiency. Thus, although immunoproteasome activity is robustly induced during acute infection with MAV-1, our data suggest that other mechanisms are capable of compensating for immunoproteasome activity to maintain antiviral immunity and appropriate inflammatory responses.
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- Contributed Indexing: Keywords: Adenovirus; Immunoproteasome; Inflammation; Interferon gamma; Myocarditis; Respiratory infection
- Accession Number: 0 (Integrin beta Chains)
0 (integrin beta5)
82115-62-6 (Interferon-gamma)
9008-11-1 (Interferons)
EC 3.4.25.1 (LMP7 protein)
EC 3.4.25.1 (Proteasome Endopeptidase Complex) - Publication Date: Date Created: 20160826 Date Completed: 20170504 Latest Revision: 20181113
- Publication Date: 20221213
- Accession Number: PMC5045817
- Accession Number: 10.1016/j.virol.2016.08.009
- Accession Number: 27560373
- Source:
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