Prevalence and Predictors of Gastroesophageal Reflux Complications in Community Subjects.

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  • Additional Information
    • Source:
      Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 7902782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2568 (Electronic) Linking ISSN: 01632116 NLM ISO Abbreviation: Dig Dis Sci Subsets: MEDLINE
    • Publication Information:
      Publication: 2005- : New York, NY : Springer Science + Business Media
      Original Publication: New York, Plenum Pub. Corp.
    • Subject Terms:
      Alcohol Drinking/*epidemiology ; Barrett Esophagus/*epidemiology ; Esophagitis, Peptic/*epidemiology ; Gastroesophageal Reflux/*epidemiology ; Obesity, Abdominal/*epidemiology ; Smoking/*epidemiology; Age Factors ; Aged ; Aged, 80 and over ; Barrett Esophagus/etiology ; Esophagitis, Peptic/etiology ; Ethnicity/statistics & numerical data ; Female ; Gastroesophageal Reflux/complications ; Humans ; Independent Living ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Prevalence ; Risk Factors ; Sex Factors ; White People/statistics & numerical data
    • Abstract:
      Background: Predictors of erosive esophagitis (EE) and Barrett's esophagus (BE) and the influence of number of risk factors in the community are not well defined.
      Methods: Rates of BE and EE among community residents identified in a randomized screening trial were defined. The risk of EE and BE associated with single and multiple risk factors (gender, age, GERD, Caucasian ethnicity, ever tobacco use, excess alcohol use, family history of BE or EAC, and central obesity) was analyzed.
      Results: Sixty-eight (33 %) of 205 subjects had EE and/or BE. BE prevalence was 7.8 % with dysplasia present in 1.5 %. Rates were comparable between subjects with and without GERD. Male sex and central obesity were independent risk factors. The odds of EE or BE were 3.7 times higher in subjects with three or four risk factors and 5.7 times higher in subjects with five or more risk factors compared with those with two or less factors.
      Conclusions: EE and BE are prevalent in the community regardless of the presence of GERD. Risk appeared to be additive, increasing substantially with three or more risk factors.
      Competing Interests: Potential competing interests: No authors have any conflicts to declare.
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    • Grant Information:
      RC4 DK090413 United States DK NIDDK NIH HHS; UL1 TR000135 United States TR NCATS NIH HHS
    • Contributed Indexing:
      Keywords: Barrett’s esophagus; Esophageal adenocarcinoma; Obesity; Predictors; Randomized trial; Screening; Transnasal endoscopy
    • Publication Date:
      Date Created: 20160812 Date Completed: 20170707 Latest Revision: 20240326
    • Publication Date:
      20240326
    • Accession Number:
      PMC5069175
    • Accession Number:
      10.1007/s10620-016-4266-3
    • Accession Number:
      27510751