Item request has been placed!
×
Item request cannot be made.
×
Processing Request
Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates: Design of a Retrospective Cohort Study.
Item request has been placed!
×
Item request cannot be made.
×
Processing Request
- Additional Information
- Corporate Authors:
- Source:
Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101615492 Publication Model: eCollection Cited Medium: Print ISSN: 2296-2360 (Print) Linking ISSN: 22962360 NLM ISO Abbreviation: Front Pediatr Subsets: PubMed not MEDLINE
- Publication Information:
Original Publication: Lausanne : Frontiers Media SA, [2013]-
- Abstract:
Introduction: Acute kidney injury (AKI) affects ~30% of hospitalized neonates. Critical to advancing our understanding of neonatal AKI is collaborative research among neonatologists and nephrologists. The Neonatal Kidney Collaborative (NKC) is an international, multidisciplinary group dedicated to investigating neonatal AKI. The AWAKEN study (Assessment of Worldwide Acute Kidney injury Epidemiology in Neonates) was designed to describe the epidemiology of neonatal AKI, validate the definition of neonatal AKI, identify primary risk factors for neonatal AKI, and investigate the contribution of fluid management to AKI events and short-term outcomes.
Methods and Analysis: The NKC was established with at least one pediatric nephrologist and neonatologist from 24 institutions in 4 countries (USA, Canada, Australia, and India). A Steering Committee and four subcommittees were created. The database subcommittee oversaw the development of the web-based database (MediData Rave™) that captured all NICU admissions from 1/1/14 to 3/31/14. Inclusion and exclusion criteria were applied to eliminate neonates with a low likelihood of AKI. Data collection included: (1) baseline demographic information; (2) daily physiologic parameters and care received during the first week of life; (3) weekly "snapshots"; (4) discharge information including growth parameters, final diagnoses, discharge medications, and need for renal replacement therapy; and (5) all serum creatinine values.
Ethics and Dissemination: AWAKEN was proposed as human subjects research. The study design allowed for a waiver of informed consent/parental permission. NKC investigators will disseminate data through peer-reviewed publications and educational conferences.
Discussion: The purpose of this publication is to describe the formation of the NKC, the establishment of the AWAKEN cohort and database, future directions, and a few "lessons learned." The AWAKEN database includes ~325 unique variables and >4 million discrete data points. AWAKEN will be the largest, most inclusive neonatal AKI study to date. In addition to validating the neonatal AKI definition and identifying risk factors for AKI, this study will uncover variations in practice patterns related to fluid provision, renal function monitoring, and involvement of pediatric nephrologists during hospitalization. The AWAKEN study will position the NKC to achieve the long-term goal of improving the lives, health, and well-being of newborns at risk for kidney disease.
- References:
Pediatrics. 1990 Sep;86(3):378-83. (PMID: 2117742)
Indian J Pediatr. 2006 Jun;73(6):499-502. (PMID: 16816511)
Cochrane Database Syst Rev. 2014;(12):CD000503. (PMID: 25473815)
J Pediatr. 2013 Apr;162(4):725-729.e1. (PMID: 23149172)
Pediatr Nephrol. 2012 Feb;27(2):303-11. (PMID: 21809002)
J Intensive Care Med. 2014 Jul-Aug;29(4):183-9. (PMID: 23753221)
Crit Care Med. 2009 Sep;37(9):2659-61. (PMID: 19687640)
Pediatr Res. 2016 Mar;79(3):502-8. (PMID: 26595535)
Curr Opin Pediatr. 2012 Apr;24(2):191-6. (PMID: 22227783)
J Pediatr Surg. 2011 Apr;46(4):630-5. (PMID: 21496529)
Pediatr Res. 2011 Apr;69(4):354-8. (PMID: 21178824)
Crit Care. 2013 Feb 04;17(1):204. (PMID: 23394211)
Kidney Int. 2007 May;71(10):1028-35. (PMID: 17396113)
Pediatr Nephrol. 2003 Sep;18(9):887-93. (PMID: 12836091)
Crit Care. 2007;11(3):R68. (PMID: 17588270)
Kidney Int. 2008 Mar;73(5):538-46. (PMID: 18160961)
Am J Kidney Dis. 2014 Apr;63(4):700-12. (PMID: 24332766)
Pediatr Nephrol. 2013 Jul;28(7):1127-34. (PMID: 23519522)
Crit Care. 2004 Aug;8(4):R204-12. (PMID: 15312219)
Pediatrics. 2001 Jun;107(6):1309-12. (PMID: 11389248)
Ren Fail. 2008;30(3):287-96. (PMID: 18350448)
Pediatrics. 2015 Aug;136(2):e463-73. (PMID: 26169430)
Pediatr Nephrol. 2013 Apr;28(4):661-6. (PMID: 23224224)
Nephron Clin Pract. 2008;109(4):c217-23. (PMID: 18802370)
Clin Dermatol. 2015 May-Jun;33(3):271-80. (PMID: 25889127)
Clin J Am Soc Nephrol. 2008 Jul;3(4):948-54. (PMID: 18417742)
J Pediatr. 2013 Jan;162(1):120-7.e1. (PMID: 22878115)
Clin J Am Soc Nephrol. 2014 Dec 5;9(12):2036-43. (PMID: 25280497)
- Grant Information:
R01 DK049419 United States DK NIDDK NIH HHS; R01 DK108368 United States DK NIDDK NIH HHS; R01 HL102497 United States HL NHLBI NIH HHS
- Contributed Indexing:
Investigator: A Akcan Arikan; A Bhutada; E Bonachea; L Boohaker; PD Brophy; AS Chishti; TT Colaizy; F Cole; C D'Angio; T Davis; M DeFreitas; J Dower; S Duara; J Fletcher; M Fuloria; J Gien; KM Gist; SL Goldstein; R Griffin; MH Hanna; S Hingorani; S Ingraham; C Joseph; S Khokhar; JM Klein; D Kumar; JC Kupferman; J Mahan; C Mammen; A Mian; L Milner; A Nada; AT Nathan; R Ohls; S Perazzo; E Rademacher; R Raina; S Rastogi; PE Ray; K Reidy; M Revenis; CJ Rhee; S Rohatgi; S Sarkar; SK Sethi; A Smith; DE Soranno; S Sridhar; A Staples; M Starr; JR Swanson; A Synnes; S Wazir; P Wintermark; CS Wong; R Woroniecki; M Zappitelli
Keywords: AWAKEN; KDIGO; NKC; acute renal failure; database; neonate
- Publication Date:
Date Created: 20160804 Date Completed: 20160803 Latest Revision: 20220317
- Publication Date:
20231215
- Accession Number:
PMC4950470
- Accession Number:
10.3389/fped.2016.00068
- Accession Number:
27486571
No Comments.