Circulating ferritin concentrations are differentially associated with serum adipokine concentrations in Japanese men and premenopausal women.

Publisher: Steinkopff Country of Publication: Germany NLM ID: 100888704 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1436-6215 (Electronic) Linking ISSN: 14366207 NLM ISO Abbreviation: Eur J Nutr Subsets: MEDLINE

Original Publication: Darmstadt, Germany : Steinkopff, 1999-

Asian People*; Adipokines/*blood ; Ferritins/*blood; Adult ; Biomarkers/blood ; Body Mass Index ; Cross-Sectional Studies ; Exercise ; Female ; Humans ; Japan ; Male ; Middle Aged ; Nicotinamide Phosphoribosyltransferase/blood ; Nutrition Assessment ; Plasminogen Activator Inhibitor 1/blood ; Premenopause

Purpose: Increased iron storage, as measured by circulating ferritin, has been linked to an increased risk of various diseases including diabetes. We examined the association of circulating ferritin with serum adiponectin, leptin, resistin, plasminogen activator inhibitor-1 (PAI-1), and visfatin levels.
Methods: We conducted a cross-sectional study among 429 Japanese employees (284 men and 145 premenopausal women, mean age: 42.5 ± 10.5 years). Serum adipokines were measured using Luminex suspension bead-based multiplexed array, and serum ferritin was determined using a chemiluminescence immunoassay. Multivariable regression analysis was performed to calculate mean concentrations of adipokine according to the tertile of ferritin concentrations with adjustment for potential confounders.
Results: Leptin and visfatin concentrations increased with increasing ferritin concentrations in men after multivariable adjustment of physical activity, smoking, alcohol use, and body mass index (P for trend = 0.02 and 0.01 for leptin and visfatin, respectively). Serum ferritin concentrations were inversely and significantly associated with adiponectin in women (P for trend = 0.01). Resistin and PAI-1 were not appreciably associated with ferritin concentration.
Conclusions: Increased iron storage may be associated with higher circulating concentrations of leptin and visfatin in men and with lower concentrations of adiponectin in women.

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Keywords: Adipokine; Adiponectin; Ferritin; Iron stores; Japanese; Leptin

0 (Adipokines)
0 (Biomarkers)
0 (Plasminogen Activator Inhibitor 1)
0 (SERPINE1 protein, human)
9007-73-2 (Ferritins)
EC 2.4.2.12 (Nicotinamide Phosphoribosyltransferase)

Date Created: 20160804 Date Completed: 20180712 Latest Revision: 20221207

20240829

10.1007/s00394-016-1285-y

27484685