Worse health-related quality of life and hip function in female patients with elevated chromium levels.

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  • Additional Information
    • Source:
      Publisher: Medical Journals Sweden AB Country of Publication: Sweden NLM ID: 101231512 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-3682 (Electronic) Linking ISSN: 17453674 NLM ISO Abbreviation: Acta Orthop Subsets: MEDLINE
    • Publication Information:
      Publication: 2022- : Uppsala, Sweden : Medical Journals Sweden AB
      Original Publication: Basingstoke, Hampshire, UK : Taylor & Francis, c2005-
    • Subject Terms:
      Metal-on-Metal Joint Prostheses* ; Quality of Life*; Arthroplasty, Replacement, Hip/*methods ; Chromium/*blood ; Hip Joint/*surgery ; Osteoarthritis, Hip/*blood ; Range of Motion, Articular/*physiology; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Female ; Follow-Up Studies ; Hip Joint/physiopathology ; Humans ; Male ; Middle Aged ; Osteoarthritis, Hip/surgery ; Prospective Studies ; Prosthesis Design ; Surveys and Questionnaires ; Time Factors ; Young Adult
    • Abstract:
      Background and purpose - Blood metal ion levels can be an indicator for detecting implant failure in metal-on-metal (MoM) hip arthroplasties. Little is known about the effect of bilateral MoM implants on metal ion levels and patient-reported outcomes. We compared unilateral patients and bilateral patients with either an ASR hip resurfacing (HR) or an ASR XL total hip replacement (THR) and investigated whether cobalt or chromium was associated with a broad spectrum of patient outcomes. Patients and methods - From a registry of 1,328 patients enrolled in a multicenter prospective follow-up of the ASR Hip System, which was recalled in 2010, we analyzed data from 659 patients (311 HR, 348 THR) who met our inclusion criteria. Cobalt and chromium blood metal ion levels were measured and a 21-item patient-reported outcome measures (PROMs) questionnaire was used mean 6 years after index surgery. Results - Using a minimal threshold of ≥7 ppb, elevated chromium ion levels were found to be associated with worse health-related quality of life (HRQoL) (p < 0.05) and hip function (p < 0.05) in women. These associations were not observed in men. Patients with a unilateral ASR HR had lower levels of cobalt ions than bilateral ASR HR patients (p < 0.001) but similar levels of chromium ions (p = 0.09). Unilateral ASR XL THR patients had lower chromium and cobalt ion levels (p < 0.005) than bilateral ASR XL THR patients. Interpretation - Chromium ion levels of ≥7 ppb were associated with reduced functional outcomes in female MoM patients.
    • References:
      J Arthroplasty. 2011 Dec;26(8):1494-500. (PMID: 21570800)
      Arthritis Care Res (Hoboken). 2011 Nov;63 Suppl 11:S240-52. (PMID: 22588748)
      J Bone Joint Surg Am. 2014 Jan 1;96(1):e4. (PMID: 24382732)
      Clin Orthop Relat Res. 2013 Feb;471(2):377-85. (PMID: 22930211)
      BMJ. 2011 May 13;342:d2905. (PMID: 21572134)
      Clin Orthop Relat Res. 2013 Feb;471(2):430-8. (PMID: 22926492)
      J Arthroplasty. 2010 Dec;25(8):1196-200. (PMID: 19879729)
      J Bone Joint Surg Am. 2009 Jul;91(7):1614-20. (PMID: 19571083)
      Acta Orthop. 2013 Jun;84(3):229-36. (PMID: 23594249)
      J Bone Joint Surg Br. 2011 May;93(5):572-9. (PMID: 21511920)
      Acta Orthop. 2013 Apr;84(2):130-7. (PMID: 23597114)
      J Arthroplasty. 2015 Jan;30(1):61-7. (PMID: 25172584)
      J Bone Joint Surg Am. 2010 Apr;92(4):840-5. (PMID: 20360506)
      Health Policy. 1990 Dec;16(3):199-208. (PMID: 10109801)
      Bone Joint Res. 2013 May 16;2(5):84-95. (PMID: 23836464)
      J Bone Joint Surg Br. 2011 Aug;93(8):1011-6. (PMID: 21768621)
      J Bone Joint Surg Am. 2014 Jul 2;96(13):1091-1099. (PMID: 24990974)
      Clin Orthop Relat Res. 2013 Sep;471(9):2964-71. (PMID: 23572350)
      J Bone Joint Surg Am. 1969 Jun;51(4):737-55. (PMID: 5783851)
      J Bone Joint Surg Br. 2008 Oct;90(10 ):1291-7. (PMID: 18827237)
      J Arthroplasty. 2004 Dec;19(8 Suppl 3):66-70. (PMID: 15578556)
      BMJ Open. 2013 Mar 12;3(3):null. (PMID: 23482990)
      J Arthroplasty. 2012 Apr;27(4):539-44. (PMID: 22000575)
      J Bone Joint Surg Am. 1984 Feb;66(2):228-41. (PMID: 6693450)
    • Accession Number:
      0 (Biomarkers)
      0R0008Q3JB (Chromium)
    • Publication Date:
      Date Created: 20160727 Date Completed: 20170221 Latest Revision: 20181113
    • Publication Date:
      20221213
    • Accession Number:
      PMC5016907
    • Accession Number:
      10.1080/17453674.2016.1213596
    • Accession Number:
      27459602