Salivary and hair glucocorticoids and sleep in very preterm children during school age.

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  • Additional Information
    • Source:
      Publisher: Pergamon Press Country of Publication: England NLM ID: 7612148 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3360 (Electronic) Linking ISSN: 03064530 NLM ISO Abbreviation: Psychoneuroendocrinology Subsets: MEDLINE
    • Publication Information:
      Original Publication: Oxford, Elmsford, N. Y., Pergamon Press.
    • Subject Terms:
      Infant, Extremely Premature*; Cortisone/*metabolism ; Hydrocortisone/*metabolism ; Hypothalamo-Hypophyseal System/*physiopathology ; Pituitary-Adrenal System/*physiopathology ; Sleep/*physiology; Child ; Female ; Hair/chemistry ; Humans ; Hypothalamo-Hypophyseal System/metabolism ; Male ; Pituitary-Adrenal System/metabolism ; Saliva/chemistry
    • Abstract:
      Very preterm birth involves increased stress for the child, which may lead to programming of the hypothalamic-pituitary-adrenal (HPA) axis activity and poor sleep in later life. Moreover, there is evidence for a relationship between HPA axis activity and sleep. However, research with objective sleep measures in very preterm children during school-age is rare. Eighty-five healthy children born very preterm (<32nd gestational week) and 91 full-term children aged 7-12 years were recruited for the present study. To assess HPA axis activity, salivary cortisol was measured at awakening, 10, 20, and 30min later. In addition, hair cortisol and cortisone concentrations were quantified using liquid chromatography tandem mass spectrometry to assess cumulative endocrine activity over the preceding months. One night of in-home polysomnographic sleep assessment was conducted to assess sleep duration, sleep continuity, and sleep architecture. Children born very preterm showed significantly lower levels of cortisol at awakening and lower overall post-awakening cortisol secretion, lower cortisone in hair, and earlier sleep onset than full-term children. Across the whole sample, overall post-awakening cortisol secretion was positively related to sleep onset time and negatively to sleep duration. The association between prematurity status and post-awakening cortisol secretion was partially mediated by earlier sleep onset time. In conclusion, this study provides evidence for a possible down-regulation of the HPA axis activity and slightly earlier sleep phase in very preterm children during school age.
      (Copyright © 2016 Elsevier Ltd. All rights reserved.)
    • Contributed Indexing:
      Keywords: Cortisol; Glucocorticoids; HPA axis activity; Preterm birth; Sleep architecture; Sleep electroencephalography
    • Accession Number:
      V27W9254FZ (Cortisone)
      WI4X0X7BPJ (Hydrocortisone)
    • Publication Date:
      Date Created: 20160720 Date Completed: 20171208 Latest Revision: 20180621
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/j.psyneuen.2016.07.003
    • Accession Number:
      27434634