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Retinol combined with retinoic acid increases retinol uptake and esterification in the lungs of young adult rats when delivered by the intramuscular as well as oral routes.
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- Author(s): Ross, A. Catharine; Nan-qian Li; Li, Nan-qian (AUTHOR)
- Source:
Journal of Nutrition. Nov2007, Vol. 137 Issue 11, p2371-2376. 6p. 1 Chart, 4 Graphs. - Source:
- Additional Information
- Subject Terms: BIOCHEMICAL research; CARDIOPULMONARY system; CAROTENES; FAT-soluble vitamins; RETINOIDS; LUNGS; VITAMIN A; TRETINOIN; PLACEBOS; VITAMIN A metabolism; ANIMAL experimentation; BIOLOGICAL transport; COMPARATIVE studies; INTRAMUSCULAR injections; LIPIDS; RESEARCH methodology; MEDICAL cooperation; ORAL drug administration; RATS; RESEARCH; RESEARCH funding; VITAMIN A deficiency; EVALUATION research; PHARMACODYNAMICS
- Abstract: The lungs require an adequate supply of vitamin A for normal embryonic development, postnatal maturation, and maintenance and repair during adult life. We have previously shown that a nutrient-metabolite combination of vitamin A admixed with a small proportion (10%) of retinoic acid (RA), referred to as VARA, acts synergistically to increase lung retinyl ester (RE) concentration in neonatal rats. A series of studies was designed to test whether VARA increases RE in adult lungs, and whether VARA is more effective than vitamin A when given by the i.m. route. Orally administered VARA increased RE in the lungs of vitamin A-marginal adult rats more than either vitamin A or RA alone (P < 0.05). In vitamin A-deficient young adult rats, lung RE was increased by VARA when administered by the i.m. route. When a tracer of (3)H-retinol was added to the placebo (oil), vitamin A, and VARA doses, total (3)H and (3)H-RE increased in the lungs more with VARA than vitamin A alone, for oral and i.m. dosing. Nevertheless, when VARA and vitamin A were given by the oral route, they were more effective in increasing RE in the liver. Plasma retinol was increased similarly in vitamin A-deficient rats after administration of VARA and vitamin A, by either the oral or the i.m. route. Overall, VARA can increase retinol uptake and esterification in adult lungs when delivered intramuscularly as well as orally. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Nutrition is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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