[Features of therapy for chronic pancreatitis associated with anxious depressive disorders in railway workers].

Publisher: Redkollegiia Zhurnala Country of Publication: Russia (Federation) NLM ID: 9434213 Publication Model: Print Cited Medium: Print ISSN: 1026-9428 (Print) Linking ISSN: 10269428 NLM ISO Abbreviation: Med Tr Prom Ekol Subsets: MEDLINE

Publication: Moskva : Redkollegiia Zhurnala
Original Publication: Moskva : Redkollegiia zhurnala, 1993-

Railroads*; Anti-Anxiety Agents/*pharmacology ; Anxiety Disorders/*physiopathology ; Depressive Disorder/*physiopathology ; Occupational Diseases/*physiopathology ; Pancreatitis, Chronic/*drug therapy ; Psychomotor Performance/*drug effects; Adult ; Anti-Anxiety Agents/adverse effects ; Anxiety Disorders/drug therapy ; Depressive Disorder/drug therapy ; Humans ; Male ; Middle Aged ; Occupational Diseases/drug therapy

The article presents data on peculiarities of chronic pancreatitis course in railway transport workers (engine operators, engine operator assistants, dispatchers) with anxious depressive disorders. Pain and dyspepsia in patients with affective disorders appeared to be constant and more intense than in the patients without concomitant anxious depression. Psychophysiologic tests in 83% of patients with comorbid conditions revealed significant psychomotor dullness manifested in reliable lower speed of visual motor reactions. Pharmacologic correction via anxiolytics (Adaptol, Afobasol) combined with standard therapy for chronic pancreatitis exacerbation enabled to improve clinical symptoms, but Adaptol appeared to slow simple visual motor reactions, therefore has to be ruled out in engine operators. Pharmacotherapy of chronic pancreatitis, that included Afobasol in addition to standard treatment, promoted reliable improvement of occupationally important psychophysiologic functions. This study received a patent.

0 (Anti-Anxiety Agents)

Date Created: 20160712 Date Completed: 20160728 Latest Revision: 20160711

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