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In vitro systems to study nephropharmacology: 2D versus 3D models.
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- Additional Information
- Source:
Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE
- Publication Information:
Publication: 2005- : Amsterdam : Elsevier Science
Original Publication: Amsterdam, North Holland Pub. Co.
- Subject Terms:
- Abstract:
The conventional 2-dimensional (2D) cell culture is an invaluable tool in, amongst others, cell biology and experimental pharmacology. However, cells cultured in 2D, on the top of stiff plastic plates lose their phenotypical characteristics and fail in recreating the physiological environment found in vivo. This is a fundamental requirement when the goal of the study is to get a rigorous predictive response of human drug action and safety. Recent approaches in the field of renal cell biology are focused on the generation of 3D cell culture models due to the more bona fide features that they exhibit and the fact that they are more closely related to the observed physiological conditions, and better predict in vivo drug handling. In this review, we describe the currently available 3D in vitro models of the kidney, and some future directions for studying renal drug handling, disease modeling and kidney regeneration.
(Copyright © 2016 Elsevier B.V. All rights reserved.)
- Contributed Indexing:
Keywords: 2D cell culture; 3D Bioprinting; Extracellular matrix; Microfluidic devices; Proximal tubule cell; Scaffold
- Publication Date:
Date Created: 20160711 Date Completed: 20170306 Latest Revision: 20170306
- Publication Date:
20240829
- Accession Number:
10.1016/j.ejphar.2016.07.010
- Accession Number:
27395797
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