Increased Velocity Storage in Subjects with Meniere's Disease.

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  • Additional Information
    • Source:
      Publisher: AVES Country of Publication: Turkey NLM ID: 101522982 Publication Model: Print Cited Medium: Print ISSN: 1308-7649 (Print) Linking ISSN: 13087649 NLM ISO Abbreviation: J Int Adv Otol Subsets: MEDLINE
    • Publication Information:
      Publication: <2016- > : İstanbul : AVES
      Original Publication: Ankara : Mediterranean Society of Otology and Audiology
    • Subject Terms:
      Vestibular Function Tests*; Meniere Disease/*physiopathology ; Neurons, Afferent/*physiology ; Vestibular Nerve/*physiopathology ; Vestibule, Labyrinth/*physiopathology; Acceleration ; Adult ; Aged ; Electric Stimulation ; Electronystagmography ; Female ; Functional Laterality ; Humans ; Male ; Middle Aged ; Reference Values ; Reflex, Vestibulo-Ocular/physiology ; Rotation ; Signal Processing, Computer-Assisted ; Synaptic Transmission/physiology
    • Abstract:
      Objective: Velocity storage mechanism is a multisensory rotation estimator; it compensates for errors in the information provided by the peripheral vestibular organs by means of an adjustment in the duration of the vestibular signal. The aim of this study was to determine the activity of the velocity storage mechanism in the presence of a labyrinthine disorder, using galvanic vestibular stimulation to cause direct activation of the vestibular afferent neurons.
      Materials and Methods: Forty-one subjects with definite Meniere's disease (MD) and 36 healthy volunteers were evaluated using a 20-s galvanic vestibular stimulation.
      Results: We found a post-stimulus nystagmus overshoot exclusively in subjects with MD (47% in subjects with unilateral disease and 82% in subjects with bilateral disease), but no overshoot in healthy subjects.
      Conclusion: Because post-stimulus nystagmus overshoot is caused by the velocity storage mechanism, this finding suggests an increase in the velocity storage in subjects with a labyrinthine disease.
    • Publication Date:
      Date Created: 20160625 Date Completed: 20160831 Latest Revision: 20161027
    • Publication Date:
      20221213
    • Accession Number:
      10.5152/iao.2016.1947
    • Accession Number:
      27340990