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Long Terminal Repeats: From Parasitic Elements to Building Blocks of the Transcriptional Regulatory Repertoire.
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- Additional Information
- Source:
Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE
- Publication Information:
Publication: Cambridge Ma : Cell Press
Original Publication: Cambridge, Mass. : Cell Press, c1997-
- Subject Terms:
- Abstract:
The life cycle of endogenous retroviruses (ERVs), also called long terminal repeat (LTR) retrotransposons, begins with transcription by RNA polymerase II followed by reverse transcription and re-integration into the host genome. While most ERVs are relics of ancient integration events, "young" proviruses competent for retrotransposition-found in many mammals, but not humans-represent an ongoing threat to host fitness. As a consequence, several restriction pathways have evolved to suppress their activity at both transcriptional and post-transcriptional stages of the viral life cycle. Nevertheless, accumulating evidence has revealed that LTR sequences derived from distantly related ERVs have been exapted as regulatory sequences for many host genes in a wide range of cell types throughout mammalian evolution. Here, we focus on emerging themes from recent studies cataloging the diversity of ERV LTRs acting as important transcriptional regulatory elements in mammals and explore the molecular features that likely account for LTR exaptation in developmental and tissue-specific gene regulation.
(Published by Elsevier Inc.)
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- Grant Information:
ZIA HD008933-02 United States Intramural NIH HHS; MOP-133417 Canada CIHR
- Accession Number:
0 (DNA, Viral)
0 (RNA, Long Noncoding)
EC 2.7.7.- (RNA Polymerase II)
EC 2.7.7.49 (RNA-Directed DNA Polymerase)
- Publication Date:
Date Created: 20160604 Date Completed: 20170814 Latest Revision: 20231111
- Publication Date:
20240829
- Accession Number:
PMC4910160
- Accession Number:
10.1016/j.molcel.2016.03.029
- Accession Number:
27259207
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