Sex-determining region Y-box3 (SOX3) functions as an oncogene in promoting epithelial ovarian cancer by targeting Src kinase.

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  • Author(s): Yan Q;Yan Q; Wang F; Wang F; Miao Y; Miao Y; Wu X; Wu X; Bai M; Bai M; Xi X; Xi X; Feng Y; Feng Y
  • Source:
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 2016 Sep; Vol. 37 (9), pp. 12263-12271. Date of Electronic Publication: 2016 Jun 01.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: IOS Press Country of Publication: Netherlands NLM ID: 8409922 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0380 (Electronic) Linking ISSN: 10104283 NLM ISO Abbreviation: Tumour Biol Subsets: MEDLINE
    • Publication Information:
      Publication: 2021- : Amsterdam, The Netherlands : IOS Press
      Original Publication: Tokyo, Japan : Saikon Pub. Co., c1984-
    • Subject Terms:
      Gene Expression Regulation, Neoplastic*; Neoplasms, Glandular and Epithelial/*genetics ; Ovarian Neoplasms/*genetics ; SOXB1 Transcription Factors/*genetics ; src-Family Kinases/*genetics; Adult ; Aged ; Aged, 80 and over ; Apoptosis/genetics ; Blotting, Western ; Carcinoma, Ovarian Epithelial ; Cell Adhesion/genetics ; Cell Line ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Female ; Humans ; Immunohistochemistry ; Microscopy, Confocal ; Middle Aged ; Neoplasms, Glandular and Epithelial/metabolism ; Neoplasms, Glandular and Epithelial/pathology ; Oncogenes/genetics ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology ; RNA Interference ; Reverse Transcriptase Polymerase Chain Reaction ; SOXB1 Transcription Factors/metabolism ; Young Adult ; src-Family Kinases/metabolism
    • Abstract:
      Ovarian cancer is one of the most common cancers which cause female mortality. The knowledge of ovarian cancer initiation and progression is critical to develop new therapeutic strategies to treat and prevent it. Recently, SOX3 has been reported to play a pivotal role in tumor progression. However, the clinical significance of SOX3 in human ovarian cancer remains elusive, and the identity of SOX3 in ovarian cancer initiation, progression, and the related underlying mechanism is unknown. In this study, we showed that SOX3 expression increased from benign and borderline to malignant ovarian tumors. Subsequently, we found that overexpression of SOX3 in EOC cells promoted proliferation, migration, and invasion, while restrained apoptosis and adhesion of ovarian cancer cells. In contrast, silencing of SOX3 gained the opposite results. Finally, we discovered SOX3 targeted Src kinase in EOC cells. These data imply that SOX3, acting as an oncogene in EOC, is not only a crucial factor in the carcinogenesis but also a promising therapeutic target for EOC.
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    • Contributed Indexing:
      Keywords: Epithelial ovarian cancer; Invasion; Migration; Proliferation; SOX3; Src
    • Accession Number:
      0 (SOX3 protein, human)
      0 (SOXB1 Transcription Factors)
      EC 2.7.10.2 (src-Family Kinases)
    • Publication Date:
      Date Created: 20160603 Date Completed: 20170221 Latest Revision: 20190221
    • Publication Date:
      20240829
    • Accession Number:
      10.1007/s13277-016-5095-x
    • Accession Number:
      27251670