Neonatal Respiratory Diseases in the Newborn Infant: Novel Insights from Stable Isotope Tracer Studies.

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  • Additional Information
    • Source:
      Publisher: Karger Country of Publication: Switzerland NLM ID: 101286577 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1661-7819 (Electronic) Linking ISSN: 16617800 NLM ISO Abbreviation: Neonatology Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel : Karger
    • Subject Terms:
      Isotopes/*pharmacokinetics ; Lung/*physiopathology ; Phosphatidylcholines/*pharmacokinetics ; Pulmonary Surfactants/*pharmacokinetics; Hernias, Diaphragmatic, Congenital/drug therapy ; Humans ; Infant, Newborn ; Infant, Premature ; Isotopes/administration & dosage ; Meconium Aspiration Syndrome/drug therapy ; Phosphatidylcholines/administration & dosage ; Pneumonia/drug therapy ; Pulmonary Surfactants/administration & dosage ; Respiratory Distress Syndrome, Newborn/drug therapy
    • Abstract:
      Respiratory distress syndrome is a common problem in preterm infants and the etiology is multifactorial. Lung underdevelopment, lung hypoplasia, abnormal lung water metabolism, inflammation, and pulmonary surfactant deficiency or disfunction play a variable role in the pathogenesis of respiratory distress syndrome. High-quality exogenous surfactant replacement studies and studies on surfactant metabolism are available; however, the contribution of surfactant deficiency, alteration or dysfunction in selected neonatal lung conditions is not fully understood. In this article, we describe a series of studies made by applying stable isotope tracers to the study of surfactant metabolism and lung water. In a first set of studies, which we call 'endogenous studies', using stable isotope-labelled intravenous surfactant precursors, we showed the feasibility of measuring surfactant synthesis and kinetics in infants using several metabolic precursors including plasma glucose, plasma fatty acids and body water. In a second set of studies, named 'exogenous studies', using stable isotope-labelled phosphatidylcholine tracer given endotracheally, we could estimate surfactant disaturated phosphatidylcholine pool size and half-life. Very recent studies are focusing on lung water and on the endogenous biosynthesis of the surfactant-specific proteins. Information obtained from these studies in infants will help to better tailor exogenous surfactant treatment in neonatal lung diseases.
      (© 2016 S. Karger AG, Basel.)
    • Accession Number:
      0 (Isotopes)
      0 (Phosphatidylcholines)
      0 (Pulmonary Surfactants)
      0 (lecithins, disaturated)
    • Publication Date:
      Date Created: 20160603 Date Completed: 20171106 Latest Revision: 20240917
    • Publication Date:
      20240917
    • Accession Number:
      10.1159/000444891
    • Accession Number:
      27251153