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Risk of Diabetes in Older Adults with Co-Occurring Depressive Symptoms and Cardiometabolic Abnormalities: Prospective Analysis from the English Longitudinal Study of Ageing.
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- Author(s): Freitas C;Freitas C;Freitas C; Deschênes S; Deschênes S; Deschênes S; Au B; Au B; Smith K; Smith K; Schmitz N; Schmitz N; Schmitz N; Schmitz N
- Source:
PloS one [PLoS One] 2016 May 26; Vol. 11 (5), pp. e0155741. Date of Electronic Publication: 2016 May 26 (Print Publication: 2016).- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
- Publication Information: Original Publication: San Francisco, CA : Public Library of Science
- Subject Terms: Aging/*pathology ; Cardiovascular Diseases/*complications ; Depression/*complications ; Diabetes Mellitus, Type 2/*etiology ; Metabolic Diseases/*complications; Adult ; Aged ; Aged, 80 and over ; Blood Glucose/metabolism ; C-Reactive Protein ; Comorbidity ; Depression/psychology ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/pathology ; Female ; Glycated Hemoglobin/analysis ; Humans ; Life Style ; Longitudinal Studies ; Male ; Middle Aged ; Prospective Studies ; Psychiatric Status Rating Scales ; Risk Factors
- Abstract: High depressive symptoms and cardiometabolic abnormalities are independently associated with an increased risk of diabetes. The purpose of this study was to assess the association of co-occurring depressive symptoms and cardiometabolic abnormalities on risk of diabetes in a representative sample of the English population aged 50 years and older. Data were from the English Longitudinal Study of Ageing. The sample comprised of 4454 participants without diabetes at baseline. High depressive symptoms were based on a score of 4 or more on the 8-item binary Centre for Epidemiologic Studies-Depression scale. Cardiometabolic abnormalities were defined as 3 or more cardiometabolic risk factors (hypertension, impaired glycemic control, systemic inflammation, low high-density lipoprotein cholesterol, high triglycerides, and central obesity). Cox proportional hazards regressions assessed the association between co-occurring depressive symptoms and cardiometabolic abnormalities with incidence of diabetes. Multiple imputation by chained equations was performed to account for missing data. Covariates included age, sex, education, income, smoking status, physical activity, alcohol consumption, and cardiovascular comorbidity. The follow-up period consisted of 106 months, during which 193 participants reported a diagnosis of diabetes. Diabetes incidence rates were compared across the following four groups: 1) no or low depressive symptoms and no cardiometabolic abnormalities (reference group, n = 2717); 2) high depressive symptoms only (n = 338); 3) cardiometabolic abnormalities only (n = 1180); and 4) high depressive symptoms and cardiometabolic abnormalities (n = 219). Compared to the reference group, the hazard ratio for diabetes was 1.29 (95% CI 0.63, 2.64) for those with high depressive symptoms only, 3.88 (95% CI 2.77, 5.44) for those with cardiometabolic abnormalities only, and 5.56 (95% CI 3.45, 8.94) for those with both high depressive symptoms and cardiometabolic abnormalities, after adjusting for socio-demographic, lifestyle and clinical variables. These findings suggest that those with high depressive symptoms and cardiometabolic abnormalities are at a particularly increased risk of type 2 diabetes.
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Epidemiology. 1996 May;7(3):286-90. (PMID: 8728443) - Accession Number: 0 (Blood Glucose)
0 (Glycated Hemoglobin A)
9007-41-4 (C-Reactive Protein) - Publication Date: Date Created: 20160527 Date Completed: 20170726 Latest Revision: 20221207
- Publication Date: 20221213
- Accession Number: PMC4882076
- Accession Number: 10.1371/journal.pone.0155741
- Accession Number: 27227974
- Source:
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