Effect of monohydroxylated flavonoids on glycation-induced lens opacity and protein aggregation.

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  • Author(s): Patil KK;Patil KK; Meshram RJ; Meshram RJ; Gacche RN; Gacche RN
  • Source:
    Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2016; Vol. 31 (sup1), pp. 148-156. Date of Electronic Publication: 2016 May 05.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basingstoke, UK : Taylor & Francis, c2002-
    • Subject Terms:
      Aldehyde Reductase/*antagonists & inhibitors ; Cataract/*drug therapy ; Cataract/*metabolism ; Enzyme Inhibitors/*pharmacology ; Flavonoids/*pharmacology ; Protein Aggregates/*drug effects; Aldehyde Reductase/metabolism ; Animals ; Enzyme Inhibitors/chemistry ; Flavonoids/chemistry ; Glycosylation ; Goats
    • Abstract:
      Glycation-induced cataractogenesis and visual impairment is a major ophthalmic concern of altered sugar homeostasis in humans as well as animals. Searching antiglycating agents from natural sources is widely acknowledged as it can be made bioavailable through diet. The present study was designed to understand the positional suitability of hydroxylation in the flavonoid scaffold for maneuvering it as an anticataract agent. Six naturally occurring monohydroxylated flavonoids rataining hydroxylation at 3, 5, 6, 7, 2' and 4' carbon position were evaluated for their effect on glycation induced lens opacity, protein aggregation, carbonyl group formation and nontryptophan fluorescence. The selected flavonoids also evaluated for their aldose reductase inhibition: a key enzyme implicated in cataractogenesis. The results of this study clearly demonstrated the stereo-specificity of hydroxyl substitution and focused the significance of 7-hydroxy substitution as a lead scaffold. Overall, the test flavonoids demonstrated considerable anti-cataract activities in context with studied parameters.
    • Contributed Indexing:
      Keywords: Cataractogenesis; flavonoids; glycation; protein aggregates
    • Accession Number:
      0 (Enzyme Inhibitors)
      0 (Flavonoids)
      0 (Protein Aggregates)
      EC 1.1.1.21 (Aldehyde Reductase)
    • Publication Date:
      Date Created: 20160506 Date Completed: 20170222 Latest Revision: 20170222
    • Publication Date:
      20240829
    • Accession Number:
      10.1080/14756366.2016.1180593
    • Accession Number:
      27149249