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Wando Mount Pleasant Library
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Village Library
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Heterocyclic Aromatic N-Oxidation in the Biosynthesis of Phenazine Antibiotics from Lysobacter antibioticus.
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- Author(s): Zhao Y;Zhao Y;Zhao Y; Qian G; Qian G; Ye Y; Ye Y; Wright S; Wright S; Chen H; Chen H; Shen Y; Shen Y; Liu F; Liu F; Liu F; Du L; Du L
- Source:
Organic letters [Org Lett] 2016 May 20; Vol. 18 (10), pp. 2495-8. Date of Electronic Publication: 2016 May 04.- Publication Type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE
- Publication Information: Original Publication: Washington, DC : American Chemical Society, c1999-
- Subject Terms: Biosynthetic Pathways*/genetics; Anti-Bacterial Agents/*isolation & purification ; Cyclic N-Oxides/*chemistry ; Hydrocarbons, Aromatic/*chemistry ; Lysobacter/*metabolism ; Phenazines/*isolation & purification; Anti-Bacterial Agents/biosynthesis ; Bacterial Proteins/genetics ; Lysobacter/enzymology ; Lysobacter/genetics ; Mixed Function Oxygenases/genetics ; Molecular Structure ; Multigene Family
- Abstract: Heterocyclic aromatic N-oxides often have potent biological activities, but the mechanism for aromatic N-oxidation is unclear. Six phenazine antibiotics were isolated from Lysobacter antibioticus OH13. A 10 gene cluster was identified for phenazine biosynthesis. Mutation of LaPhzNO1 abolished all N-oxides, while non-oxides markedly increased. LaPhzNO1 is homologous to Baeyer-Villiger flavoproteins but was shown to catazlye phenazine N-oxidation. LaPhzNO1 and LaPhzS together converted phenazine 1,6-dicarboxylic acid to 1,6-dihydroxyphenazine N5,N10-dioxide. LaPhzNO1 also catalyzed N-oxidation of 8-hydroxyquinoline.
- Grant Information: R01 AI097260 United States AI NIAID NIH HHS
- Accession Number: 0 (Anti-Bacterial Agents)
0 (Bacterial Proteins)
0 (Cyclic N-Oxides)
0 (Hydrocarbons, Aromatic)
0 (Phenazines)
EC 1.- (Mixed Function Oxygenases) - Publication Date: Date Created: 20160505 Date Completed: 20180621 Latest Revision: 20180621
- Publication Date: 20221213
- Accession Number: 10.1021/acs.orglett.6b01089
- Accession Number: 27145204
- Source:
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