Pathophysiology of Radiation-Induced Dysphagia in Head and Neck Cancer.

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  • Additional Information
    • Source:
      Publisher: Springer-Verlag Country of Publication: United States NLM ID: 8610856 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0460 (Electronic) Linking ISSN: 0179051X NLM ISO Abbreviation: Dysphagia Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York : Springer-Verlag, [c1986-
    • Subject Terms:
      Chemoradiotherapy/*adverse effects ; Deglutition Disorders/*physiopathology ; Head and Neck Neoplasms/*therapy ; Radiation Injuries/*physiopathology; Deglutition Disorders/etiology ; Humans ; Radiation Injuries/etiology
    • Abstract:
      Oncologic treatments, such as curative radiotherapy and chemoradiation, for head and neck cancer can cause long-term swallowing impairments (dysphagia) that negatively impact quality of life. Radiation-induced dysphagia comprised a broad spectrum of structural, mechanical, and neurologic deficits. An understanding of the biomolecular effects of radiation on the time course of wound healing and underlying morphological tissue responses that precede radiation damage will improve options available for dysphagia treatment. The goal of this review is to discuss the pathophysiology of radiation-induced injury and elucidate areas that need further exploration.
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    • Grant Information:
      K99 HL111215 United States HL NHLBI NIH HHS; R00 HL111215 United States HL NHLBI NIH HHS
    • Contributed Indexing:
      Keywords: Cancer; Deglutition; Deglutition disorders; Fibrosis; Pharynx; Radiation; Swallow
    • Publication Date:
      Date Created: 20160422 Date Completed: 20180102 Latest Revision: 20240610
    • Publication Date:
      20240610
    • Accession Number:
      PMC5340192
    • Accession Number:
      10.1007/s00455-016-9710-1
    • Accession Number:
      27098922