Dynamic Analysis of Changes of Protein Levels and Selected Biochemical Indices in Rat Serum in the Course of Experimental Pleurisy.

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  • Additional Information
    • Source:
      Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 7600105 Publication Model: Print Cited Medium: Internet ISSN: 1573-2576 (Electronic) Linking ISSN: 03603997 NLM ISO Abbreviation: Inflammation Subsets: MEDLINE
    • Publication Information:
      Publication: 1999- : New York, NY : Kluwer Academic/Plenum Publishers
      Original Publication: New York, Plenum Press.
    • Subject Terms:
      Acute-Phase Proteins/*analysis ; Blood Proteins/*analysis ; Pleurisy/*blood; Acute-Phase Proteins/metabolism ; Animals ; Blood Proteins/metabolism ; Disease Models, Animal ; Female ; Interleukin-1/biosynthesis ; Interleukin-1/blood ; Interleukin-6/biosynthesis ; Interleukin-6/blood ; Rats ; Rats, Inbred BUF ; Time Factors ; Tumor Necrosis Factor-alpha/biosynthesis ; Tumor Necrosis Factor-alpha/blood
    • Abstract:
      A significant role is played in inflammation by the liver, which, stimulated by inflammatory mediators, synthetizes plasma proteins with various dynamics. The purpose of these studies is to generate a detailed dynamic analysis of changes to concentrations of plasma and serum protein fractions and selected acute-phase proteins as well as nonspecific biochemical indices during the course of an induced pleurisy. The studies were conducted on female inbred Buffalo rats, which were divided into two groups: a control group (C) and an experimental group (IP) in which pleurisy was induced. In the IP group, significant changes in biochemical indices were observed between the 48th and 96th hours of pleurisy. A reduction of albumin, transferrin, urea, and creatinine concentrations was observed, while concentrations of the complement components C3 and C4, haptoglobin, and fibrinogen increased. An early increase of IL-1 was observed, while increases of IL-6 and TNF were noted in the later period. The maximum intensity of the processes described above occurred between the 72nd and 96th hours of pleurisy.
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    • Contributed Indexing:
      Keywords: acute-phase proteins; electrophoresis of serum proteins; inflammatory reaction; pleurisy
    • Accession Number:
      0 (Acute-Phase Proteins)
      0 (Blood Proteins)
      0 (Interleukin-1)
      0 (Interleukin-6)
      0 (Tumor Necrosis Factor-alpha)
    • Publication Date:
      Date Created: 20160417 Date Completed: 20170309 Latest Revision: 20181113
    • Publication Date:
      20221213
    • Accession Number:
      PMC4883275
    • Accession Number:
      10.1007/s10753-016-0339-x
    • Accession Number:
      27083876