[A Case Report of a Pathological Complete Response of Rectal Cancer to Preoperative Chemoradiotherapy with Tegafur].

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  • Author(s): Morikawa T;Morikawa T; Teraishi F; Shima Y; Iwata J
  • Source:
    Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2016 Mar; Vol. 43 (3), pp. 381-4.
  • Publication Type:
    Case Reports; English Abstract; Journal Article
  • Language:
    Japanese
  • Additional Information
    • Source:
      Publisher: Gan To Kagaku Ryohosha Country of Publication: Japan NLM ID: 7810034 Publication Model: Print Cited Medium: Print ISSN: 0385-0684 (Print) Linking ISSN: 03850684 NLM ISO Abbreviation: Gan To Kagaku Ryoho Subsets: MEDLINE
    • Publication Information:
      Publication: Tokyo : Gan To Kagaku Ryohosha
      Original Publication: Tōkyō, Gan to Kagaku Ryōhōsha [1974?]-
    • Subject Terms:
      Chemoradiotherapy*; Antimetabolites, Antineoplastic/*therapeutic use ; Oxonic Acid/*therapeutic use ; Rectal Neoplasms/*pathology ; Rectal Neoplasms/*therapy ; Tegafur/*therapeutic use; Aged ; Biopsy ; Drug Combinations ; Humans ; Male ; Neoplasm Staging ; Treatment Outcome
    • Abstract:
      We report the case of a patient with advanced rectal cancer who achieved a pathological complete response to preoperative chemoradiotherapy (CRT). A 65-year-old man was diagnosed as having a two-thirds circumferential well-to moderately differentiated tumor (Rb-P, type 2). To control local recurrence, we treated the patient with CRT. Radiotherapy was administered in fractions of 2 Gy/day (total, 40 Gy). Concurrently, S-1 was administered orally at a fixed daily dose of 80 mg/m2 for 20 days. Withdrawal and/or dose reduction of S-1 was not necessary in spite of Grade 1 or 2 toxic effects, including diarrhea and periproctitis, occurring on day 7. Laparoscopic abdominoperineal resection was performed 6 weeks after the final dose of chemotherapy was administered. The histopathological regression grade was Grade 3. No recurrence was detected on enhanced CT more than 5 years after surgery. This case suggests that the regimen was both effective and tolerated, and that preoperative chemoradiotherapy may be effective for tumor suppression to prevent local recurrence.
    • Accession Number:
      0 (Antimetabolites, Antineoplastic)
      0 (Drug Combinations)
      150863-82-4 (S 1 (combination))
      1548R74NSZ (Tegafur)
      5VT6420TIG (Oxonic Acid)
    • Publication Date:
      Date Created: 20160413 Date Completed: 20160526 Latest Revision: 20160412
    • Publication Date:
      20221213
    • Accession Number:
      27067861