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Wando Mount Pleasant Library
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Donepezil for the Treatment of Agitation in Alzheimer's Disease.
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- Author(s): Howard, Robert J.; Juszczak, Edmund; Ballard, Clive G.; Bentham, Peter; Brown, Richard G.; Bullock, Roger; Burns, Alistair S.; Holmes, Clive; Jacoby, Robin; Johnson, Tony; Knapp, Martin; Lindesay, James; O'Brien, John T.; Wilcock, Gordon; Katona, Cornelius; Jones, Roy W.; DeCesare, Julia; Rodger, Michaela
- Source:
New England Journal of Medicine. 10/4/2007, Vol. 357 Issue 14, p1382-1392. 11p. 2 Diagrams. - Source:
- Additional Information
- Subject Terms:
- Abstract: Background: Agitation is a common and distressing symptom in patients with Alzheimer's disease. Cholinesterase inhibitors improve cognitive outcomes in such patients, but the benefits of these drugs for behavioral disturbances are unclear. Methods: We randomly assigned 272 patients with Alzheimer's disease who had clinically significant agitation and no response to a brief psychosocial treatment program to receive 10 mg of donepezil per day (128 patients) or placebo (131 patients) for 12 weeks. The primary outcome was a change in the score on the Cohen–Mansfield Agitation Inventory (CMAI) (on a scale of 29 to 203, with higher scores indicating more agitation) at 12 weeks. Results: There was no significant difference between the effects of donepezil and those of placebo on the basis of the change in CMAI scores from baseline to 12 weeks (estimated mean difference in change [the value for donepezil minus that for placebo], −0.06; 95% confidence interval [CI], −4.35 to 4.22). Twenty-two of 108 patients (20.4%) in the placebo group and 22 of 113 (19.5%) in the donepezil group had a reduction of 30% or greater in the CMAI score (the value for donepezil minus that for placebo, −0.9 percentage point; 95% CI, −11.4 to 9.6). There were also no significant differences between the placebo and donepezil groups in scores for the Neuropsychiatric Inventory, the Neuropsychiatric Inventory Caregiver Distress Scale, or the Clinician's Global Impression of Change. Conclusions: In this 12-week trial, donepezil was not more effective than placebo in treating agitation in patients with Alzheimer's disease. (ClinicalTrials.gov number, NCT00142324.) N Engl J Med 2007;357:1382-92. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of New England Journal of Medicine is the property of New England Journal of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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