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West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
Closed
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. - 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. - 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. - 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
2 p.m. – 6 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. - 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. - 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. - 8 p.m.
Phone: (843) 805-6892
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9 a.m. - 5 p.m.
Phone: (843) 805-6909
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Profiling Meta-Analysis Reveals Primarily Gene Coexpression Concordance between Systemic Lupus Erythematosus and Rheumatoid Arthritis.
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- Author(s): SILVA, GUILHERME L.; JUNTA, CRISTINA M.; MELLO, STEPHANO S.; GARCIA, PAULA S.; RASSI, DIANE M.; SAKAMOTO‐HOJO, ELZA T.; DONADI, EDUARDO A.; PASSOS, GERALDO A. S.
- Source:
Annals of the New York Academy of Sciences; Sep2007, Vol. 1110, p33-46, 14p, 1 Diagram, 1 Chart- Subject Terms:
- Source:
- Additional Information
- Abstract: Consensus gene expression profiling by meta-analysis of 4,500 cDNA sequence microarray data obtained from patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) was assembled and systematically analyzed. The normalized data were statistically analyzed by the significance analysis of microarray (SAM) program (false discovery rate ≤ 0.01). Patient data input was realized together, in the Cluster and Tree-View program, using the unsupervised function. Individual expression signatures permitted a hierarchical clustering of samples, separately identifying SLE and RA patients and the transcriptome profiling featured modules of the specifically induced or repressed and the comodulated genes. Gene expression profiling meta-analysis showed that patients with SLE or RA share gene modulation but also present genes whose expression patterns are exclusive (induced or repressed) in corroboration with their clinical features. Among the genes that were differentially expressed, we found those that could play specific roles in these two diseases. This approach permits a clearer understanding of the molecular basis of SLE and RA concordance/divergence. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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