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West Ashley Library
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Phone: (843) 766-6635
Folly Beach Library
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Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
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Wando Mount Pleasant Library
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Phone: (843) 805-6888
Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 8 p.m.
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Mt. Pleasant Library
9 a.m. - 8 p.m.
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McClellanville Library
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Hurd/St. Andrews Library
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Miss Jane's Building (Edisto Library Temporary Location)
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Dorchester Road Library
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Phone: (843) 805-6930
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X Monosomy in Female Systemic Lupus Erythematosus.
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- Author(s): INVERNIZZI, PIETRO; MIOZZO, MONICA; OERTELT‐PRIGIONE, SABINE; MERONI, PIER LUIGI; PERSANI, LUCA; SELMI, CARLO; BATTEZZATI, PIER MARIA; ZUIN, MASSIMO; LUCCHI, SIMONA; MARASINI, BIANCA; ZENI, SILVANA; WATNIK, MITCHELL; TABANO, SILVIA; MAITZ, SILVIA; PASINI, SIMONE; GERSHWIN, M. ERIC; PODDA, MAURO
- Source:
Annals of the New York Academy of Sciences; Sep2007, Vol. 1110, p84-91, 8p, 1 Chart, 1 Graph- Subject Terms:
- Source:
- Additional Information
- Abstract: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, predominantly occurring in women of childbearing age. SLE, like several other autoimmune diseases, is characterized by a striking female predominance and, although sex hormone influences have been suggested as an explanation for this phenomenon, definitive data are still unavailable. Our group recently reported an increased X monosomy in lymphocytes of women, affected with primary biliary cirrhosis (PBC), systemic sclerosis (SSc), and autoimmune thyroiditis (AITD) in comparison to healthy women, thus suggesting the involvement of this chromosome in female predominance and in the deregulation of the immune system that characterizes autoimmunity. We have now evaluated X monosomy rates in SLE using fluorescence in situ hybridization (FISH) on peripheral mononuclear white blood cells (PBMCs) from female patients compared to healthy age-matched controls. In addition, because of a previous finding of microchimerism as a pathogenetic cause of a number of autoimmune diseases, we investigated the presence of cells carrying the Y chromosome. We did not identify an increased X monosomy in women with SLE compared to controls ( P= 0.3960, SLE vs. HCs, Student's t-test), thus suggesting that a different mechanism of immune deregulation might be predominant in the female population of patients with SLE. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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