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Immunophenotypic markers in adult acute lymphoblastic leukemia: the prognostic significance of CD20 and TdT expression.
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- Author(s): Kim DY;Kim DY; Park HS; Park HS; Choi EJ; Choi EJ; Lee JH; Lee JH; Lee JH; Lee JH; Jeon M; Jeon M; Kang YA; Kang YA; Lee YS; Lee YS; Seol M; Seol M; Cho YU; Cho YU; Jang S; Jang S; Chi HS; Chi HS; Lee KH; Lee KH; Park CJ; Park CJ
- Source:
Blood research [Blood Res] 2015 Dec; Vol. 50 (4), pp. 227-34. Date of Electronic Publication: 2015 Dec 21.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Springer Nature Country of Publication: Korea (South) NLM ID: 101605247 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2287-979X (Print) Linking ISSN: 2287979X NLM ISO Abbreviation: Blood Res Subsets: PubMed not MEDLINE
- Publication Information: Publication: 2024- : [Cham, Switzerland] : Springer Nature
Original Publication: Seoul : Korean Society of Hematology - Abstract: Background: Efforts to overcome poor outcomes in patients with adult acute lymphoblastic leukemia (ALL) have focused on combining new therapeutic agents targeting immunophenotypic markers (IPMs) with classical cytotoxic agents; therefore, it is important to evaluate the clinical significance of IPMs.
Methods: Baseline characteristics and clinical outcomes of patients with adult ALL were retrospectively analyzed. The percentage of blasts expressing IPMs at diagnosis was measured by multicolor flow cytometry analysis. Samples in which ≥20% of blasts expressed an IPM were considered positive.
Results: Among the total patient population (N=230), almost all (92%) were in first or second hematological complete remission (HCR) and 54% received allogeneic hematopoietic cell transplant (allo-HCT). Five-year hematologic relapse-free survival (HRFS) and overall survival (OS) rates were 36% and 39%, respectively, and 45.6% and 80.5% of patients were positive for the IPMs CD20 and terminal deoxynucleotidyl transferase (TdT), respectively. Expression of CD20, CD13, CD34, and TdT was associated with HRFS rate, and expression of CD20 and CD13 was associated with OS rate, as was the performance of allo-HCT. In multivariate analysis, positivity for CD20 (HRFS: hazard ratio [HR], 2.21, P<0.001; OS: HR, 1.63, P=0.015) and negativity for TdT (HRFS: HR, 2.30, P=0.001) were both significantly associated with outcomes. When patients were categorized into three subgroups according to positivity for CD20 and TdT, there were significant differences in HRFS and OS among the subgroups.
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J Clin Oncol. 2010 Aug 20;28(24):3880-9. (PMID: 20660823) - Contributed Indexing: Keywords: Acute lymphoblastic leukemia; CD20; Immunophenotypic markers; TdT
- Publication Date: Date Created: 20160116 Date Completed: 20160115 Latest Revision: 20200930
- Publication Date: 20240628
- Accession Number: PMC4705048
- Accession Number: 10.5045/br.2015.50.4.227
- Accession Number: 26770950
- Source:
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