Translocation of microbes and changes of immunocytes in the gut of rapid- and slow-progressor Chinese rhesus macaques infected with SIVmac239.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read Online Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 0374672 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2567 (Electronic) Linking ISSN: 00192805 NLM ISO Abbreviation: Immunology Subsets: MEDLINE
    • Publication Information:
      Original Publication: Oxford : Blackwell Scientific Publications
    • Subject Terms:
      Gastrointestinal Microbiome*; Intestinal Mucosa/*cytology ; Intestinal Mucosa/*immunology ; Simian Acquired Immunodeficiency Syndrome/*immunology ; Simian Acquired Immunodeficiency Syndrome/*virology ; Simian Immunodeficiency Virus/*immunology; Animals ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Disease Progression ; Intestinal Mucosa/microbiology ; Intestinal Mucosa/pathology ; Intestinal Mucosa/virology ; Lymphocyte Count ; Macaca mulatta ; Macrophages/immunology ; Macrophages/metabolism ; Male ; Phagocytosis/immunology ; Viral Load
    • Abstract:
      Human/simian immunodeficiency virus (HIV/SIV) infection can cause severe depletion of CD4(+) T cells in both plasma and mucosa; it also results in damage to the gut mucosa barrier, which makes the condition more conducive to microbial translocation. In this study, we used SIV-infected Chinese rhesus macaques to quantify the extent of microbial translocation and the function of immune cells in the entire gastrointestinal tract and to compare their differences between rapid and slow progressors. The results showed that in the slow progressors, microbial products translocated considerably and deeply into the lamina propria of the gut; the tissue macrophages had no significant differences compared with the rapid progressors, but there was a slightly higher percentage of mucosal CD8(+) T cells and a large amount of extracellular microbial products in the lamina propria of the intestinal mucosa of the slow progressors. The data suggested that although microbial translocation increased markedly, the mucosal macrophages and CD8(+) T cells were insufficient to clear the infiltrated microbes in the slow progressors. Also, therapies aimed at suppressing the translocation of microbial products in the mucosa could help to delay the progression of SIV disease.
      (© 2016 John Wiley & Sons Ltd.)
    • References:
      J Virol. 2013 Jun;87(12):7032-8. (PMID: 23596288)
      AIDS Rev. 2013 Jan-Mar;15(1):32-7. (PMID: 23449227)
      Retrovirology. 2014;11:14. (PMID: 24495380)
      Am J Reprod Immunol. 2014 Jun;71(6):537-42. (PMID: 24689691)
      Gut Microbes. 2014 Jul 1;5(4):562-70. (PMID: 25078714)
      J Virol. 2001 Nov;75(21):10515-9. (PMID: 11581423)
      J Virol. 2003 Nov;77(21):11708-17. (PMID: 14557656)
      Nat Immunol. 2004 Oct;5(10):987-95. (PMID: 15454922)
      J Immunol. 1992 Oct 15;149(8):2816-22. (PMID: 1383328)
      Science. 1998 Apr 17;280(5362):427-31. (PMID: 9545219)
      J Clin Invest. 2005 Jan;115(1):66-75. (PMID: 15630445)
      J Virol. 2005 Mar;79(5):2709-19. (PMID: 15708990)
      Nature. 2005 Apr 28;434(7037):1148-52. (PMID: 15793562)
      Immunol Rev. 2005 Aug;206:149-59. (PMID: 16048547)
      Curr HIV/AIDS Rep. 2007 Feb;4(1):10-5. (PMID: 17338855)
      Semin Immunol. 2007 Apr;19(2):84-93. (PMID: 17055292)
      J Clin Invest. 2007 Aug;117(8):2197-204. (PMID: 17657310)
      AIDS. 2008 Oct 1;22(15):2035-8. (PMID: 18784466)
      Gastroenterology. 2009 May;136(6):1965-78. (PMID: 19462506)
      J Virol. 2009 Dec;83(23):12229-40. (PMID: 19759147)
      J Infect Dis. 2010 Apr 15;201(8):1150-4. (PMID: 20199244)
      J Med Primatol. 2010 Aug;39(4):243-51. (PMID: 20618590)
      PLoS Pathog. 2010;6(8):e1001052. (PMID: 20808901)
      Retrovirology. 2010;7:102. (PMID: 21118577)
      Immunol Res. 2011 Apr;49(1-3):135-46. (PMID: 21170741)
      PLoS Pathog. 2011 May;7(5):e1002060. (PMID: 21637819)
      J Clin Invest. 2011 Nov;121(11):4433-45. (PMID: 22005304)
      Annu Rev Immunol. 2012;30:149-73. (PMID: 22224779)
      J Clin Invest. 2012 May;122(5):1712-6. (PMID: 22523065)
      Trends Microbiol. 2013 Jan;21(1):6-13. (PMID: 23062765)
      Virol J. 2012;9:269. (PMID: 23150992)
      PLoS Pathog. 2013 Feb;9(2):e1003195. (PMID: 23468632)
      Clin Dev Immunol. 2013;2013:631063. (PMID: 24348678)
    • Contributed Indexing:
      Keywords: lamina propria; microbial translocation; mucosa; simian immunodeficiency virus
    • Publication Date:
      Date Created: 20160105 Date Completed: 20160809 Latest Revision: 20181113
    • Publication Date:
      20231215
    • Accession Number:
      PMC4799887
    • Accession Number:
      10.1111/imm.12574
    • Accession Number:
      26725773