[Heme oxygenase-1 - more than the cytoprotection].

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  • Author(s): Kozakowska M; Dulak J; Józkowicz A
  • Source:
    Postepy biochemii [Postepy Biochem] 2015; Vol. 61 (2), pp. 147-58.
  • Publication Type:
    Journal Article; Review
  • Language:
    Polish
  • Additional Information
    • Transliterated Title:
      Oksygenaza hemowa-4 - więcej niż cytoprotekcja.
    • Source:
      Publisher: Panstwowe Wydawnictwo Naukowe Country of Publication: Poland NLM ID: 0023525 Publication Model: Print Cited Medium: Print ISSN: 0032-5422 (Print) Linking ISSN: 00325422 NLM ISO Abbreviation: Postepy Biochem Subsets: MEDLINE
    • Publication Information:
      Publication: Warszawa : Panstwowe Wydawnictwo Naukowe
      Original Publication: Warszawa.
    • Subject Terms:
      Cell Differentiation* ; Neovascularization, Physiologic*; Heme Oxygenase-1/*physiology ; Immune System/*enzymology; Cell Cycle ; Cytoprotection ; Gene Expression Regulation ; Heme Oxygenase-1/genetics ; Heme Oxygenase-1/immunology ; Humans
    • Abstract:
      Heme oxygenase-1 (HO-1) is an enzyme degrading heme to three products - ferrous ions, carbon monoxide and biliverdin. Its function extends, however, far beyond removal of pro-oxidative heme from microenvironment. During the last few decades it was proven that apart from cytoprotective and antioxidative properties HO-1 regulates also a variety of cellular processes. It exerts an impact on both innate and adaptive immune response. HO-1 accelerates development of new blood vessels in a process called angiogenesis. Moreover, it controls cell cycle and depending on a cell type increases or decreases the rate of cell division. Finally, the most recent data indicate, that HO-1 regulates also differentiation of various stem and progenitor cells. Interestingly, that aspect of HO-1 function seems also to depend on cell type. In this review, both effects and mechanisms of above-mentioned processes in different cell types are discussed.
    • Accession Number:
      EC 1.14.14.18 (Heme Oxygenase-1)
    • Publication Date:
      Date Created: 20151223 Date Completed: 20160302 Latest Revision: 20220321
    • Publication Date:
      20221213
    • Accession Number:
      26689007