[Chimeric Antigen Receptor T-cells -  Gene Therapy of the Future for Malignant Diseases?].

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  • Author(s): Šmída M
  • Source:
    Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti [Klin Onkol] 2015; Vol. 28 Suppl 4, pp. 4S44-7.
  • Publication Type:
    English Abstract; Journal Article; Review
  • Language:
    Czech
  • Additional Information
    • Transliterated Title:
      Chimérický antigenní receptor T lymfocytů -  genová terapie budoucnosti u nádorových onemocnění?
    • Source:
      Publisher: Ceská lékarská spolecnost Country of Publication: Czech Republic NLM ID: 9425213 Publication Model: Print Cited Medium: Print ISSN: 0862-495X (Print) Linking ISSN: 0862495X NLM ISO Abbreviation: Klin Onkol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Brno : Ceská lékarská spolecnost,
    • Subject Terms:
      Genetic Therapy*; Neoplasms/*therapy ; Receptors, Antigen, T-Cell/*genetics ; Recombinant Fusion Proteins/*genetics ; T-Lymphocytes/*immunology; Humans ; T-Lymphocytes/metabolism
    • Abstract:
      Chimeric antigen receptors are synthetic, genetically modified receptors of T-cells. The introduction of chimeric antigen receptors into autologous patient T-cells can redirect the lymphocytes to specific antigen targets on the surface of malignant cells. This has recently emerged as an intriguing therapy approach in both hematologic malignancies and later also in solid tumors. Various chimeric antigen receptor designs and manufacturing processes were developed and seem to have a strong impact on the activity of chimeric antigen receptor T-lymphocytes and thereby the therapy success. The individual variables are currently being tested in numerous clinical trials. In this review, I will briefly describe the principle, basic structure and construction of chimeric antigen receptor T-lymphocytes.
    • Accession Number:
      0 (Receptors, Antigen, T-Cell)
      0 (Recombinant Fusion Proteins)
    • Publication Date:
      Date Created: 20151210 Date Completed: 20160111 Latest Revision: 20191113
    • Publication Date:
      20240829
    • Accession Number:
      10.14735/amko20154s44
    • Accession Number:
      26647888