Incidence of Autoantibodies to C1Q Complement Component in Women with Miscarriages and Autoantibodies to Phospholipids and Chorionic Gonadotropin.

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  • Additional Information
    • Source:
      Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-8221 (Electronic) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE
    • Publication Information:
      Publication: New York : Springer
      Original Publication: New York, Consultants Bureau.
    • Subject Terms:
      Abortion, Spontaneous/*blood ; Abortion, Spontaneous/*immunology ; Autoantibodies/*blood ; Autoantibodies/*immunology ; Chorionic Gonadotropin/*immunology ; Complement C1q/*immunology ; Phospholipids/*immunology; Complement C3/metabolism ; Complement C4/metabolism ; Female ; Humans ; Pregnancy
    • Abstract:
      Autoantibodies to C1q complement component are often detected in patients with autoimmune diseases. The complement system is involved in the pathophysiology of gestosis. The incidence of anti-C1q autoantibodies was studied in women with miscarriages and autoantibodies to phospholipids and chorionic gonadotropin. Serum C3 and C4 complement components and anti-C1Q autoantibodies (IgG) were measured by ELISA. The median levels of C3 and C4 in patients with miscarriages were lower than in healthy women. Anti-C1q autoantibodies were more often found in the patients than in controls; patients with autoantibodies to phospholipids formed a risk group. Median levels of anti-C1q autoantibodies were higher in the patients with autoantibodies to phospholipids and chorionic gonadotropin than in healthy women. Hence, activation of the complement system and hyperproduction of anti-C1q autoantibodies were unfolding in patients with miscarriages, mainly in the patients with autoantibodies to phospholipids.
    • Contributed Indexing:
      Keywords: antiphospholipid autoantibodies; autoantibodies to chorionic gonadotropin; autoantibodies to complement C1q component; miscarriage
    • Accession Number:
      0 (Autoantibodies)
      0 (Chorionic Gonadotropin)
      0 (Complement C3)
      0 (Complement C4)
      0 (Phospholipids)
      80295-33-6 (Complement C1q)
    • Publication Date:
      Date Created: 20151208 Date Completed: 20160920 Latest Revision: 20151209
    • Publication Date:
      20250114
    • Accession Number:
      10.1007/s10517-015-3144-x
    • Accession Number:
      26639463