Menu
×
West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. – 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. – 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. – 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. – 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. – 8 p.m.
Phone: (843) 766-2546
Folly Beach Library
Closed
Phone: (843) 588-2001
Dorchester Road Library
9 a.m. – 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. – 7 p.m.
Phone: (843) 722-7550
Bees Ferry West Ashley Library
9 a.m. – 8 p.m.
Phone: (843) 805-6892
Baxter-Patrick James Island
9 a.m. – 8 p.m.
Phone: (843) 795-6679
Miss Jane's Building (Edisto Library Temporary Location)
Closed
Phone: (843) 869-2355
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Main Library
9 a.m. – 6 p.m.
Phone: (843) 805-6930
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Today's Hours
West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. – 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. – 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. – 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. – 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. – 8 p.m.
Phone: (843) 766-2546
Folly Beach Library
Closed
Phone: (843) 588-2001
Dorchester Road Library
9 a.m. – 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. – 7 p.m.
Phone: (843) 722-7550
Bees Ferry West Ashley Library
9 a.m. – 8 p.m.
Phone: (843) 805-6892
Baxter-Patrick James Island
9 a.m. – 8 p.m.
Phone: (843) 795-6679
Miss Jane's Building (Edisto Library Temporary Location)
Closed
Phone: (843) 869-2355
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Main Library
9 a.m. – 6 p.m.
Phone: (843) 805-6930
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Patron Login
menu
Item request has been placed!
×
Item request cannot be made.
×
Processing Request
[ACUTE CORONARY SYNDROME AND LIPID-LOWERING THERAPY. DOES THE IMPROVE-IT STUDY MAKE ANY DIFFERENCE?].
Item request has been placed!
×
Item request cannot be made.
×
Processing Request
- Author(s): Lancellotti P; Pierard LA; Scheen AJ
- Source:
Revue medicale de Liege [Rev Med Liege] 2015 Sep; Vol. 70 (9), pp. 450-5.- Publication Type:
Comparative Study; English Abstract; Journal Article; Randomized Controlled Trial- Language:
French - Source:
- Additional Information
- Transliterated Title: Syndrome coronarien aigu et traitement hypolipémiant. L'étude IMPROVE-IT change-t-elle la donne?
- Source: Publisher: Hopital De Baviere Country of Publication: Belgium NLM ID: 0404317 Publication Model: Print Cited Medium: Print ISSN: 0370-629X (Print) Linking ISSN: 0370629X NLM ISO Abbreviation: Rev Med Liege Subsets: MEDLINE
- Publication Information: Publication: Liege : Hopital De Baviere
Original Publication: Liège. - Subject Terms: Acute Coronary Syndrome/*drug therapy ; Anticholesteremic Agents/*therapeutic use ; Cardiovascular Diseases/*prevention & control ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use; Anticholesteremic Agents/administration & dosage ; Anticholesteremic Agents/adverse effects ; Cardiovascular Diseases/epidemiology ; Cholesterol, LDL/drug effects ; Dose-Response Relationship, Drug ; Double-Blind Method ; Drug Therapy, Combination ; Ezetimibe/administration & dosage ; Ezetimibe/adverse effects ; Ezetimibe/therapeutic use ; Female ; Follow-Up Studies ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Male ; Middle Aged ; Prognosis ; Simvastatin/administration & dosage ; Simvastatin/adverse effects ; Simvastatin/therapeutic use ; Treatment Outcome
- Abstract: Statins reduce both LDL cholesterol (LDL-C) levels and the risk of cardiovascular events in patients with and without cardiovascular disease. Intensive statin therapy, compared with moderate-dose statin therapy, incrementally lowers LDL-C levels and rates of cardiovascular events in patients presenting with acute coronary syndrome. Ezetimibe, by diminishing the absorption of cholesterol from the intestine, additionally reduces LDL-C when added to statins. In this article, we discuss the potential benefits of the combination of simvastatin and ezetimibe for the long-term management of patients with acute coronary syndrome through an analysis of the IMPROVE-IT results (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial). This randomised double blind trial included 18,144 patients with a LDL-C of 50 to 100 (with statin) or 125 (without statin) mg/dl and had a median follow-up of 6 years. The objective of the study was to test the efficacy of simvastatin 40 mg versus simvastatin 40 mg and 10 mg ezetimibe. The primary endpoint included cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina and coronary revascularization. The addition of ezetimibe to simvastatin resulted in an incremental lowering of LDL-C (reached value 53.2 versus 69.9 mg/dl, p < 0.001) and a further improvement of the patient prognosis (relative reduction of primary endpoint: -6.4%, p = 0.016). In addition, the combined therapy showed no significant adverse effects, particularly regarding the risk of cancers, which confirms the safety of ezetimibe. In acute coronary syndrome, the prescription of ezetimibe should be considered (class HA, level of evidence B) in patients with a LDL-C a 70 mg/dl despite maximally tolerated dose of statin.
- Accession Number: 0 (Anticholesteremic Agents)
0 (Cholesterol, LDL)
0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
AGG2FN16EV (Simvastatin)
EOR26LQQ24 (Ezetimibe) - Publication Date: Date Created: 20151208 Date Completed: 20151222 Latest Revision: 20151207
- Publication Date: 20231215
- Accession Number: 26638446
- Transliterated Title:
Contact CCPL
Copyright 2022 Charleston County Public Library Powered By EBSCO Stacks 3.3.0 [350.3] | Staff Login
No Comments.