The Function of Autophagy in Neurodegenerative Diseases.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Alzheimer Disease/*genetics ; Amyotrophic Lateral Sclerosis/*genetics ; Autophagy/*genetics ; Huntington Disease/*genetics ; Parkinson Disease/*genetics; AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/pathology ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Autophagy-Related Protein-1 Homolog ; Beclin-1 ; Gene Expression Regulation ; Humans ; Huntington Disease/metabolism ; Huntington Disease/pathology ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Lysosomes/metabolism ; Mechanistic Target of Rapamycin Complex 1 ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Multiprotein Complexes/genetics ; Multiprotein Complexes/metabolism ; Neurons/metabolism ; Neurons/pathology ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism

Macroautophagy, hereafter referred to as autophagy, is a bulk degradation process performed by lysosomes in which aggregated and altered proteins as well as dysfunctional organelles are decomposed. Autophagy is a basic cellular process that maintains homeostasis and is crucial for postmitotic neurons. Thus, impaired autophagic processes in neurons lead to improper homeostasis and neurodegeneration. Recent studies have suggested that impairments of the autophagic process are associated with several neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and static encephalopathy of childhood with neurodegeneration in adulthood. In this review, we focus on the recent findings regarding the autophagic process and the involvement of autophagy in neurodegenerative diseases.

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Keywords: ALS; Alzheimer’s disease; Huntington’s disease; Parkinson’s disease; SENDA; autophagy; mitophagy

0 (Apoptosis Regulatory Proteins)
0 (BECN1 protein, human)
0 (Beclin-1)
0 (Intracellular Signaling Peptides and Proteins)
0 (Membrane Proteins)
0 (Multiprotein Complexes)
EC 2.7.11.1 (Autophagy-Related Protein-1 Homolog)
EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
EC 2.7.11.1 (Protein Serine-Threonine Kinases)
EC 2.7.11.1 (TOR Serine-Threonine Kinases)
EC 2.7.11.1 (ULK1 protein, human)
EC 2.7.11.31 (AMP-Activated Protein Kinases)

Date Created: 20151117 Date Completed: 20160829 Latest Revision: 20220321

20221213

PMC4661849

10.3390/ijms161125990

26569220