Menu
×
West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
Closed
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. - 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. - 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. - 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
2 p.m. – 6 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. - 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. - 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. - 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Today's Hours
West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
Closed
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. - 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. - 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. - 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
2 p.m. – 6 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. - 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. - 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. - 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Patron Login
menu
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Gut microbiota and host metabolism in liver cirrhosis.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Usami M;Usami M; Miyoshi M; Miyoshi M; Yamashita H; Yamashita H
- Source:
World journal of gastroenterology [World J Gastroenterol] 2015 Nov 07; Vol. 21 (41), pp. 11597-608.- Publication Type:
Journal Article; Review- Language:
English - Source:
- Additional Information
- Source: Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 100883448 Publication Model: Print Cited Medium: Internet ISSN: 2219-2840 (Electronic) Linking ISSN: 10079327 NLM ISO Abbreviation: World J Gastroenterol Subsets: MEDLINE
- Publication Information: Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group
Original Publication: Beijing : WJG Press, c1998- - Subject Terms: Energy Metabolism* ; Gastrointestinal Microbiome*; Bacteria/*metabolism ; Intestinal Mucosa/*metabolism ; Intestines/*microbiology ; Liver Cirrhosis/*metabolism ; Liver Cirrhosis/*microbiology; Animals ; Bacteria/pathogenicity ; Bacterial Translocation ; Dysbiosis ; Host-Pathogen Interactions ; Humans ; Liver Cirrhosis/therapy ; Probiotics/therapeutic use
- Abstract: The gut microbiota has the capacity to produce a diverse range of compounds that play a major role in regulating the activity of distal organs and the liver is strategically positioned downstream of the gut. Gut microbiota linked compounds such as short chain fatty acids, bile acids, choline metabolites, indole derivatives, vitamins, polyamines, lipids, neurotransmitters and neuroactive compounds, and hypothalamic-pituitary-adrenal axis hormones have many biological functions. This review focuses on the gut microbiota and host metabolism in liver cirrhosis. Dysbiosis in liver cirrhosis causes serious complications, such as bacteremia and hepatic encephalopathy, accompanied by small intestinal bacterial overgrowth and increased intestinal permeability. Gut dysbiosis in cirrhosis and intervention with probiotics and synbiotics in a clinical setting is reviewed and evaluated. Recent studies have revealed the relationship between gut microbiota and host metabolism in chronic metabolic liver disease, especially, non-alcoholic fatty liver disease, alcoholic liver disease, and with the gut microbiota metabolic interactions in dysbiosis related metabolic diseases such as diabetes and obesity. Recently, our understanding of the relationship between the gut and liver and how this regulates systemic metabolic changes in liver cirrhosis has increased. The serum lipid levels of phospholipids, free fatty acids, polyunsaturated fatty acids, especially, eicosapentaenoic acid, arachidonic acid, and docosahexaenoic acid have significant correlations with specific fecal flora in liver cirrhosis. Many clinical and experimental reports support the relationship between fatty acid metabolism and gut-microbiota. Various blood metabolome such as cytokines, amino acids, and vitamins are correlated with gut microbiota in probiotics-treated liver cirrhosis patients. The future evaluation of the gut-microbiota-liver metabolic network and the intervention of these relationships using probiotics, synbiotics, and prebiotics, with sufficient nutrition could aid the development of treatments and prevention for liver cirrhosis patients.
- References: Liver Int. 2013 Sep;33(8):1148-57. (PMID: 23601333)
J Proteome Res. 2011 Dec 2;10(12):5512-22. (PMID: 21970572)
Nature. 2013 Dec 19;504(7480):446-50. (PMID: 24226770)
FEMS Microbiol Rev. 2005 Sep;29(4):625-51. (PMID: 16102595)
Gut. 2003 Oct;52(10):1442-7. (PMID: 12970137)
Neurosci Lett. 2004 Jan 23;355(1-2):105-8. (PMID: 14729246)
Biochem Pharmacol. 2013 Oct 1;86(7):926-39. (PMID: 23928191)
Gastroenterology. 2015 Jan;148(1):30-6. (PMID: 25447847)
Biology (Basel). 2014 Dec 15;3(4):892-921. (PMID: 25517881)
J Hepatol. 2014 Jan;60(1):197-209. (PMID: 23993913)
Am J Physiol Gastrointest Liver Physiol. 2012 Jan 1;302(1):G1-9. (PMID: 22016433)
Science. 2012 Jun 8;336(6086):1262-7. (PMID: 22674330)
JPEN J Parenter Enteral Nutr. 2011 May;35(3):317-28. (PMID: 21527594)
Am J Transplant. 2005 Jan;5(1):125-30. (PMID: 15636620)
Nature. 2012 Feb 9;482(7384):179-85. (PMID: 22297845)
Trends Microbiol. 2004 Jan;12(1):14-20. (PMID: 14700547)
Nat Rev Neurosci. 2012 Oct;13(10):701-12. (PMID: 22968153)
J Pharmacol Sci. 2010;112(1):19-24. (PMID: 20093784)
J Clin Lipidol. 2011 Jul-Aug;5(4):288-93. (PMID: 21784374)
Ann Hepatol. 2008 Apr-Jun;7(2):120-4. (PMID: 18626428)
World J Hepatol. 2015 Mar 27;7(3):559-65. (PMID: 25848479)
Chin J Dig Dis. 2004;5(2):64-7. (PMID: 15612659)
Biol Psychiatry. 2013 Nov 15;74(10):720-6. (PMID: 23759244)
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16767-72. (PMID: 18931303)
Am J Clin Nutr. 2009 May;89(5):1393-401. (PMID: 19357220)
Clin Nutr. 2011 Apr;30(2):252-8. (PMID: 21051124)
Gastroenterol Res Pract. 2010;2010:null. (PMID: 20706677)
Mol Endocrinol. 2014 Aug;28(8):1221-38. (PMID: 24892638)
Clin Nutr. 2013 Jun;32(3):444-51. (PMID: 23068014)
J Hepatol. 2006 Nov;45(5):744-57. (PMID: 16979776)
Gut Liver. 2012 Apr;6(2):149-71. (PMID: 22570745)
Scand J Gastroenterol. 2003 Oct;38(10):1039-44. (PMID: 14621277)
J Lipid Res. 2006 Feb;47(2):241-59. (PMID: 16299351)
Biochem J. 2011 Aug 1;437(3):357-72. (PMID: 21749321)
Am J Gastroenterol. 2008 Jul;103(7):1707-15. (PMID: 18691193)
Clin Nutr. 2009 Dec;28(6):657-61. (PMID: 19523724)
Am J Physiol Gastrointest Liver Physiol. 2012 Dec 1;303(11):G1288-95. (PMID: 23064760)
Med Hypotheses. 2010 May;74(5):895-7. (PMID: 19962247)
Nutrition. 2011 Feb;27(2):177-81. (PMID: 20452184)
Nutrition. 2005 Jul-Aug;21(7-8):838-47. (PMID: 15975492)
Curr Opin Clin Nutr Metab Care. 2013 Sep;16(5):576-81. (PMID: 23873346)
Gut. 2012 Apr;61(4):543-53. (PMID: 22110050)
Aliment Pharmacol Ther. 2014 May;39(10):1113-25. (PMID: 24628464)
Nutrition. 1998 Jul-Aug;14(7-8):563-72. (PMID: 9684258)
Nurs Res. 2010 Nov-Dec;59(6):426-32. (PMID: 21048484)
Eur J Gastroenterol Hepatol. 2007 Dec;19(12):1111-3. (PMID: 17998837)
Liver Int. 2013 Nov;33(10):1470-7. (PMID: 23968203)
Dig Dis Sci. 2013 Mar;58(3):660-7. (PMID: 23344966)
J Clin Gastroenterol. 2008 Jul;42 Suppl 2:S80-4. (PMID: 18542037)
Eur J Clin Pharmacol. 2009 Jun;65(6):561-70. (PMID: 19326107)
Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4578-85. (PMID: 20668239)
PLoS Genet. 2009 Dec;5(12):e1000785. (PMID: 20041198)
Dig Dis Sci. 2012 Dec;57(12):3126-35. (PMID: 22684624)
Nature. 2013 Jul 4;499(7456):97-101. (PMID: 23803760)
J Pharmacol Exp Ther. 1994 Nov;271(2):660-70. (PMID: 7525940)
World J Gastroenterol. 2012 Dec 14;18(46):6693-700. (PMID: 23239905)
Alcohol. 2004 Aug;34(1):9-19. (PMID: 15670660)
World J Gastroenterol. 2015 Feb 14;21(6):1691-702. (PMID: 25684933)
Behav Brain Res. 2015 Jan 15;277:32-48. (PMID: 25078296)
J Clin Biochem Nutr. 2012 Jan;50(1):59-66. (PMID: 22247602)
Metabolism. 2014 May;63(5):607-17. (PMID: 24629562)
J Clin Endocrinol Metab. 1997 Nov;82(11):3864-71. (PMID: 9360553)
J Clin Gastroenterol. 2005 Jul;39(6):540-3. (PMID: 15942443)
Hepatology. 2001 Jul;34(1):101-8. (PMID: 11431739)
World J Hepatol. 2015 Mar 27;7(3):425-42. (PMID: 25848468)
J Hepatol. 2012;56 Suppl 1:S56-65. (PMID: 22300466)
J Nutr. 2005 Jan;135(1):9-13. (PMID: 15623825)
Fed Proc. 1986 Jun;45(7):2060-4. (PMID: 3519290)
J Hepatol. 2011 Mar;54(3):432-8. (PMID: 21093950)
Nutrition. 2008 Nov-Dec;24(11-12):1189-98. (PMID: 18723323)
Curr Pharm Des. 2014;20(10):1487-98. (PMID: 23789956)
Nutrition. 2010 Jun;26(6):653-61. (PMID: 20004081)
Nature. 2011 Apr 7;472(7341):57-63. (PMID: 21475195)
J Appl Microbiol. 2012 Aug;113(2):411-7. (PMID: 22612585)
Obes Rev. 2013 Dec;14(12):950-9. (PMID: 23947604)
Curr Opin Lipidol. 2002 Feb;13(1):61-7. (PMID: 11790964)
Gastroenterology. 2014 May;146(6):1513-24. (PMID: 24440671)
Int J Mol Sci. 2014;15(1):684-711. (PMID: 24402126)
Liver Int. 2014 Nov;34(10):1504-12. (PMID: 24661740)
Microbiol Immunol. 2007;51(1):25-35. (PMID: 17237596)
Clin Gastroenterol Hepatol. 2014 Jun;12(6):1003-8.e1. (PMID: 24246768)
Am J Surg. 2011 Apr;201(4):498-502. (PMID: 20619394)
J Biol Chem. 2011 Dec 16;286(50):43301-12. (PMID: 22025614)
Psychoneuroendocrinology. 2012 Sep;37(9):1369-78. (PMID: 22483040)
Gut. 1994 Jan;35(1 Suppl):S35-8. (PMID: 8125387)
Altern Med Rev. 2008 Dec;13(4):292-306. (PMID: 19152477)
Neurogastroenterol Motil. 2009 Dec;21(12):1239-49. (PMID: 19650771)
J Clin Gastroenterol. 2006 Mar;40(3):235-43. (PMID: 16633129)
PLoS Pathog. 2012;8(7):e1002829. (PMID: 22911431)
J Proteome Res. 2010 Oct 1;9(10):5284-95. (PMID: 20806900)
Clin Nutr. 2010 Jun;29(3):365-9. (PMID: 19897285)
Gastroenterology. 2006 Feb;130(2 Suppl 1):S78-90. (PMID: 16473077)
Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4523-30. (PMID: 20837534)
Front Pharmacol. 2010 Oct 04;1:124. (PMID: 21833169)
Transplantation. 2002 Jul 15;74(1):123-7. (PMID: 12134110)
Lipids. 2010 May;45(5):429-36. (PMID: 20405232)
J Hepatol. 2013 May;58(5):1020-7. (PMID: 23183530)
Neuropeptides. 2012 Dec;46(6):261-74. (PMID: 22979996)
Diabetes. 2007 Jul;56(7):1761-72. (PMID: 17456850)
J Basic Microbiol. 1993;33(1):59-72. (PMID: 8478793)
Am J Clin Nutr. 1979 Jan;32(1):173-8. (PMID: 367144)
Cell Host Microbe. 2012 Oct 18;12(4):496-508. (PMID: 23084918)
J Physiol. 2014 Jul 15;592(14):2927-41. (PMID: 24566540)
J Biol Chem. 2011 Jul 8;286(27):23637-43. (PMID: 21566124)
Gastroenterology. 2011 Aug;141(2):599-609, 609.e1-3. (PMID: 21683077)
Int J Microbiol. 2012;2012:694629. (PMID: 22848224)
J Nutr Biochem. 2002 Jun;13(6):364-369. (PMID: 12088802) - Contributed Indexing: Keywords: Fatty acids; Liver cirrhosis; Metabolism; Microbiota; Probiotics
- Publication Date: Date Created: 20151112 Date Completed: 20161031 Latest Revision: 20181202
- Publication Date: 20240628
- Accession Number: PMC4631963
- Accession Number: 10.3748/wjg.v21.i41.11597
- Accession Number: 26556989
- Source:
Contact CCPL
Copyright 2022 Charleston County Public Library Powered By EBSCO Stacks 3.3.0 [350.3] | Staff Login
No Comments.