Chemical exposure levels in printing and coating workers with cholangiocarcinoma (third report).

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  • Author(s): Yamada K;Yamada K; Kumagai S; Kubo S; Endo G
  • Source:
    Journal of occupational health [J Occup Health] 2015; Vol. 57 (6), pp. 565-71. Date of Electronic Publication: 2015 Oct 07.
  • Publication Type:
    Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: John Wiley & Sons Australia, Ltd on behalf of The Japan Society for Occupational Health Country of Publication: Australia NLM ID: 9616320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1348-9585 (Electronic) Linking ISSN: 13419145 NLM ISO Abbreviation: J Occup Health Subsets: MEDLINE
    • Publication Information:
      Publication: 2019- : [Milton, Queensland, Australia] : John Wiley & Sons Australia, Ltd on behalf of The Japan Society for Occupational Health
      Original Publication: Tokyo : Japan Society for Occupational Health, [1996-
    • Subject Terms:
      Printing*; Bile Duct Neoplasms/*chemically induced ; Cholangiocarcinoma/*chemically induced ; Methylene Chloride/*analysis ; Occupational Exposure/*analysis ; Propane/*analogs & derivatives; Aged ; Environmental Monitoring ; Humans ; Ink ; Japan ; Male ; Methylene Chloride/toxicity ; Middle Aged ; Occupational Diseases/chemically induced ; Occupational Exposure/adverse effects ; Propane/analysis ; Propane/toxicity ; Time Factors
    • Abstract:
      Objective: This study aimed to identify the chemicals used by five printing workers and one coating worker who developed cholangiocarcinoma and estimate the workers' levels of chemical exposure.
      Methods: We obtained information on chemicals from the Ministry of Health, Labour and Welfare, Japan, and estimated working environment concentrations of the chemicals in printing and coating rooms and exposure concentrations during the ink and dirt removal processes. We also calculated shift time-weighted averages of exposure concentrations.
      Results: All five printing workers were exposed to both 1,2-dichloropropane (1,2-DCP) and dichloromethane (DCM). The estimated maximum exposure concentrations for each of the five workers were 190 to 560 ppm for 1,2-DCP and 300 to 980 ppm for DCM, and the estimated shift average exposure concentrations were 0 to 230 ppm for 1,2-DCP and 20 to 470 ppm for DCM. The coating worker was exposed to 1,2-DCP, but not DCM. He did not use ink, and thus was subjected to different conditions than the printing workers. The estimated maximum exposure concentration of 1,2-DCP was 150 ppm, and the estimated shift time-weighted average exposure concentration was 5 to 19 ppm.
      Conclusions: Our findings support the notion that 1,2-DCP contributes to the development of cholangiocarcinoma in humans and the notion that DCM may also be a contributing factor. The finding that the coating worker was exposed to 1,2-DCP at a lower exposure concentration is important for determining the occupational exposure limit. Furthermore, the subject did not use ink, which suggests that ink did not contribute to the development of cholangiocarcinoma.
    • References:
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      J Hepatobiliary Pancreat Sci. 2014 Jul;21(7):479-88. (PMID: 24420816)
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    • Accession Number:
      588X2YUY0A (Methylene Chloride)
      RRZ023OFWL (propylene dichloride)
      T75W9911L6 (Propane)
    • Publication Date:
      Date Created: 20151009 Date Completed: 20160929 Latest Revision: 20200225
    • Publication Date:
      20221213
    • Accession Number:
      PMC6706177
    • Accession Number:
      10.1539/joh.15-0170-OA
    • Accession Number:
      26447094