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Hypodermin A, a potential agent for prevention of allogeneic acute rejection.
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- Author(s): Chen Q;Chen Q; Chen R; Chen R; Liu J; Liu J; Yuan H; Yuan H; Liu P; Liu P; Hu A; Hu A; Wu L; Wu L; Fang L; Fang L; Fang L; Xiao S; Xiao S; Xiao S; Zhu X; Zhu X
- Source:
Transplant immunology [Transpl Immunol] 2015 Nov; Vol. 33 (3), pp. 198-203. Date of Electronic Publication: 2015 Sep 26.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9309923 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5492 (Electronic) Linking ISSN: 09663274 NLM ISO Abbreviation: Transpl Immunol Subsets: MEDLINE
- Publication Information: Publication: Amsterdam : Elsevier
Original Publication: Dunton Green, Sevenoaks, Kent, UK : Edward Arnold, c1993- - Subject Terms: Graft Rejection/*therapy ; Macrophages/*physiology ; Serine Endopeptidases/*metabolism; Acute Disease ; Animals ; Cattle ; Cell Line ; Cytokines/metabolism ; Dinoprostone/metabolism ; Diptera/immunology ; Graft Rejection/immunology ; Humans ; Immunosuppression Therapy ; Mice ; Receptors, Prostaglandin E, EP4 Subtype/metabolism ; Serine Endopeptidases/genetics ; Transgenes/genetics
- Abstract: Immunosuppressive agents play an important role in the success of organ transplantation, however the chronic toxicity of these agents is a major issue over the long-term. Hypodermin A (HA) is an enzyme secreted by the larvae of Hypoderma lineatum (Diptera: Oestridae), and has been implicated in immunosuppression in cattle. Malassagne et al. have demonstrated that HA can degrade the C3 protein, and could be used to prevent hyperacute xenogeneic rejection. We found that overexpression of HA in RAW264.7 cells induced significant secretion of prostaglandin E2 (PGE2), which mediates a variety of innate and adaptive immune responses through four E-type prostanoid (EP) receptor subtypes (EP1-4). PGE2 is useful in the management of allogeneic acute rejection. In addition, we found that induction of PGE2 expression downregulates the expression of interferon (IFN)-γ and interleukin (IL)-2, and promotes the secretion of IL-10 in vitro through the EP4 receptor. It was previously shown that activation of IL-2 and IFN-γ is involved in allograft acute rejection. IL-10 is known to prevent inflammation, and can improve allograft survival rates. We concluded that besides preventing hyperacute xenogeneic rejection, HA might also be a potential therapeutic candidate for ameliorating acute rejection during allotransplantation.
(Copyright © 2015 Elsevier B.V. All rights reserved.) - Contributed Indexing: Keywords: Allotransplantation; Hypodermin A; PGE(2); Transplant rejection
- Accession Number: 0 (Cytokines)
0 (Receptors, Prostaglandin E, EP4 Subtype)
EC 3.4.21.- (Serine Endopeptidases)
EC 3.4.21.- (hypodermin)
K7Q1JQR04M (Dinoprostone) - Publication Date: Date Created: 20150930 Date Completed: 20160829 Latest Revision: 20211203
- Publication Date: 20231215
- Accession Number: 10.1016/j.trim.2015.09.004
- Accession Number: 26416179
- Source:
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