Intracranial versus Extracranial Symptomatic Carotid Atherosclerosis in Chinese Patients: Risk Factors, Stroke Mechanisms, and Long-Term Prognosis.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Saunders Country of Publication: United States NLM ID: 9111633 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8511 (Electronic) Linking ISSN: 10523057 NLM ISO Abbreviation: J Stroke Cerebrovasc Dis Subsets: MEDLINE
    • Publication Information:
      Publication: Philadelphia, PA : Saunders
      Original Publication: New York, NY : Demos Publications, [1991-
    • Subject Terms:
      Carotid Artery Diseases/*complications ; Carotid Artery, External/*pathology ; Carotid Artery, Internal/*pathology ; Stroke/*complications; Adult ; Aged ; Aged, 80 and over ; Brain/pathology ; China ; Female ; Humans ; Image Processing, Computer-Assisted ; Longitudinal Studies ; Magnetic Resonance Angiography ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Prognosis ; Risk Factors ; Statistics, Nonparametric
    • Abstract:
      Objectives: This study aims to investigate the clinical-radiological features and stroke mechanisms of symptomatic intracranial internal carotid artery (IICA) atherosclerosis and prognoses of patients with IICA atherosclosis, and compare these data with those from patients with symptomatic extranial carotid artery (EICA) atherosclerosis.
      Methods: We prospectively recruited 155 patients with symptomatic IICA or EICA atherosclerosis (stenosis ≥50% or occlusion) from 1968 Chinese patients with a first-ever ischemic stroke or transient ischemic attack. The patients were followed up for stroke recurrence, cardiovascular events, and death.
      Results: There were 80 and 75 patients in the IICA and EICA groups, respectively. Multivariate logistic regression analyses showed that the patients in the IICA group were associated with hypertension (odds ratio [OR], 5.980; 95% confidence interval [CI], 1.790-19.976) and asymptomatic intracranial atherosclerosis (OR, 2.564; 95% CI, 1.222-5.377), while the patients in the EICA group were associated with smoking (OR, 2.397; 95% CI, 1.150-4.998) and contralateral EICA disease (OR, 4.742; 95% CI, 1.455-15.455). Hemodynamic stroke alone was more common in the IICA group; artery-to-artery embolism was identified more often in the EICA group (P <.05). The cumulative incidences of ipsilateral stroke recurrence, stroke recurrence and cardiovascular events, and death at 5 years were 43.5%, 52.4%, and 27.3%, respectively, in the patients of the IICA group, which did not differ from those of the EICA group.
      Conclusions: IICA atherosclerosis as well as EICA atherosclerosis is an important cause of stroke in Chinese patients. Patients with symptomatic IICA atherosclerosis had unique clinical-radiological features and stroke mechanisms compared with those with symptomatic EICA atherosclerosis; their long-term prognosis was poor.
      (Copyright © 2015 National Stroke Association. Published by Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: Internal carotid artery; atherosclerosis; prognosis; risk factor; stroke mechanisms; stroke recurrence
    • Publication Date:
      Date Created: 20150926 Date Completed: 20160809 Latest Revision: 20151102
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/j.jstrokecerebrovasdis.2015.07.019
    • Accession Number:
      26403366