Prospective data from the Women's Health Initiative on depressive symptoms, stress, and inflammation.

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  • Additional Information
    • Source:
      Publisher: Sage Publications Country of Publication: England NLM ID: 9703616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1461-7277 (Electronic) Linking ISSN: 13591053 NLM ISO Abbreviation: J Health Psychol Subsets: MEDLINE
    • Publication Information:
      Original Publication: London ; Thousand Oaks, CA : Sage Publications, 1996-
    • Subject Terms:
      Women's Health*; Depression/*complications ; Inflammation/*complications ; Stress, Psychological/*complications; Aged ; Biomarkers/blood ; C-Reactive Protein/metabolism ; Chronic Disease ; Depression/blood ; Depression/diagnosis ; Depression/psychology ; Female ; Humans ; Inflammation/blood ; Inflammation/diagnosis ; Inflammation/psychology ; Longitudinal Studies ; Middle Aged ; Prospective Studies ; Stress, Psychological/blood ; Stress, Psychological/diagnosis ; Stress, Psychological/psychology ; Surveys and Questionnaires
    • Abstract:
      This study examined the longitudinal association of depressive symptoms and stressful life events with inflammation in the Women's Health Initiative. Women aged 50 years and older ( N = 7477) completed questionnaires assessing depressive symptoms and stressful life events at baseline and 15 years later. Serum measures of C-reactive protein were collected at both assessments. In bivariate analyses, C-reactive protein predicted 15-year depressive symptoms and stressful life events ( ps < .03) and baseline depressive symptoms and stressful life events predicted later C-reactive protein ( ps < .03). These longitudinal relationships were not maintained in multivariate adjusted analyses. Combined with previous research, this suggests the relationship between depression, stressful life events and inflammation attenuates with time.
    • Grant Information:
      T32 AG027677 United States AG NIA NIH HHS; HHSN268201100046C United States HL NHLBI NIH HHS; HHSN268201100001C United States WH WHI NIH HHS; HHSN268201100002C United States WH WHI NIH HHS; HHSN268201100003C United States WH WHI NIH HHS; HHSN268201100004C United States WH WHI NIH HHS; HHSN271201100004C United States AG NIA NIH HHS
    • Contributed Indexing:
      Keywords: depression; inflammation; psychological distress; stress; women’s health
    • Accession Number:
      0 (Biomarkers)
      9007-41-4 (C-Reactive Protein)
    • Publication Date:
      Date Created: 20150910 Date Completed: 20180404 Latest Revision: 20181213
    • Publication Date:
      20221213
    • Accession Number:
      10.1177/1359105315603701
    • Accession Number:
      26349616