Clinical outcome and predictors of treatment response in foam sodium tetradecyl sulfate sclerotherapy of venous malformations.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Springer International Country of Publication: Germany NLM ID: 9114774 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1084 (Electronic) Linking ISSN: 09387994 NLM ISO Abbreviation: Eur Radiol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Berlin : Springer International, c1991-
    • Subject Terms:
      Sclerotherapy/*methods ; Sodium Tetradecyl Sulfate/*therapeutic use ; Vascular Malformations/*therapy; Adolescent ; Adult ; Child ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Retrospective Studies ; Sclerosing Solutions/therapeutic use ; Treatment Outcome ; Vascular Malformations/diagnosis ; Young Adult
    • Abstract:
      Objectives: To evaluate clinical outcomes and their predictors in patients with venous malformation (VM) treated with foam sodium tetradecyl sulfate (STS) sclerotherapy.
      Methods: We retrospectively evaluated clinical outcomes of foam STS sclerotherapy in 86 patients with 91 VMs to assess reduction in pain and mass after treatment. Univariate and multivariate analysis was performed to determine possible predictors of clinical outcome with foam STS sclerotherapy.
      Results: A positive response of 49.5% in pain reduction and 52.7% in mass reduction was observed. The numerical rating scale (NRS) score improved from 4.36 ± 2.64 to 1.74 ± 1.57, and VM mass volume decreased to 41.7 ± 35.52% of the initial size. On multivariate analysis, a high baseline NRS score (odds ratio: 1.12, 95% confidence interval: 1.09-1.15) and VM location in the trunk versus the head and neck (odds ratio: 1.30, 95% confidence interval: 1.00-1.69) were positive predictors of pain improvement. Minor complications occurred in 11 (12.1%) patients and recurrence in 12 (13.2%) patients.
      Conclusions: Foam STS sclerotherapy is an effective treatment in venous malformation, with low complication risk. A high baseline NRS score and location in the trunk versus the head and neck were positive predictors in improvement of pain.
      Key Points: • Foam STS sclerotherapy is effective in VM, with low risk of complications. • Relief of pain tends to be dramatic in patients with severe pain. • Location of VM is a predictor of pain improvement. • The presence of a draining vein does not affect foam sclerotherapy.
    • References:
      J Vasc Surg. 2009 Sep;50(3):581-9, 589.e1. (PMID: 19540703)
      Radiology. 2002 Jun;223(3):639-44. (PMID: 12034929)
      Orthop Clin North Am. 2006 Jul;37(3):435-74, vii-viii. (PMID: 16846771)
      Cardiovasc Intervent Radiol. 2014 Aug;37(4):977-89. (PMID: 24196269)
      Radiographics. 2001 Nov-Dec;21(6):1519-31. (PMID: 11706222)
      J Vasc Surg. 2008 Mar;47(3):578-84. (PMID: 18295109)
      AJNR Am J Neuroradiol. 2010 May;31(5):955-60. (PMID: 20044505)
      Semin Dermatol. 1993 Jun;12(2):88-97. (PMID: 8512799)
      Eur J Radiol. 2005 Jan;53(1):35-45. (PMID: 15607851)
      Int Angiol. 2015 Apr;34(2):97-149. (PMID: 24566499)
      Plast Reconstr Surg. 1999 Jul;104(1):1-11; discussion 12-5. (PMID: 10597669)
      Pediatr Radiol. 2003 Feb;33(2):99-103. (PMID: 12557065)
      Am J Nurs. 1999 Dec;99(12):22. (PMID: 10738379)
      J Nucl Med. 2009 Feb;50(2):239-49. (PMID: 19164218)
      J Vasc Interv Radiol. 2007 Mar;18(3):343-51. (PMID: 17377179)
      Circulation. 1976 Dec;54(6):969-74. (PMID: 991413)
      J Vasc Interv Radiol. 2004 May;15(5):431-45. (PMID: 15126652)
      J Vasc Surg. 2001 Apr;33(4):764-72. (PMID: 11296330)
      Eur J Vasc Endovasc Surg. 2012 Jun;43(6):721-5. (PMID: 22507925)
      Eur J Vasc Endovasc Surg. 2010 Mar;39(3):366-71. (PMID: 20080424)
      J Dermatol Surg Oncol. 1987 May;13(5):547-50. (PMID: 3571692)
      Eur J Cancer. 2009 Jan;45(2):228-47. (PMID: 19097774)
      J Vasc Surg. 2010 Apr;51(4):940-5. (PMID: 20347690)
      J Vasc Interv Radiol. 2010 Jan;21(1):81-9. (PMID: 20123194)
      J Vasc Surg. 2003 Mar;37(3):533-8. (PMID: 12618688)
      Cardiovasc Intervent Radiol. 1996 Mar-Apr;19(2):65-71. (PMID: 8729181)
      Radiographics. 1990 Sep;10 (5):787-96. (PMID: 2217971)
      Semin Intervent Radiol. 2010 Dec;27(4):391-9. (PMID: 22550381)
      Pain. 2001 Nov;94(2):149-58. (PMID: 11690728)
      AJR Am J Roentgenol. 1997 Sep;169(3):723-9. (PMID: 9275886)
      AJR Am J Roentgenol. 2010 Aug;195(2):281-9. (PMID: 20651182)
      Semin Intervent Radiol. 2010 Jun;27(2):209-31. (PMID: 21629410)
    • Contributed Indexing:
      Keywords: Phlebography; Sclerosing solutions; Sclerotherapy; Vascular malformations; Venous malformation
    • Accession Number:
      0 (Sclerosing Solutions)
      Q1SUG5KBD6 (Sodium Tetradecyl Sulfate)
    • Publication Date:
      Date Created: 20150827 Date Completed: 20161213 Latest Revision: 20220409
    • Publication Date:
      20221213
    • Accession Number:
      10.1007/s00330-015-3931-9
    • Accession Number:
      26307182