Occupational protein contact dermatitis.

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  • Additional Information
    • Source:
      Publisher: John Libbey Eurotext Country of Publication: France NLM ID: 9206420 Publication Model: Print Cited Medium: Internet ISSN: 1952-4013 (Electronic) Linking ISSN: 11671122 NLM ISO Abbreviation: Eur J Dermatol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Montrouge, France : John Libbey Eurotext, c1991-
    • Subject Terms:
      Dermatitis, Allergic Contact*/diagnosis ; Dermatitis, Allergic Contact*/etiology ; Dermatitis, Allergic Contact*/immunology ; Dermatitis, Occupational*/diagnosis ; Dermatitis, Occupational*/etiology ; Dermatitis, Occupational*/immunology; Hypersensitivity, Immediate/*chemically induced ; Occupational Exposure/*adverse effects ; Proteins/*adverse effects ; Skin/*pathology; Humans ; Hypersensitivity, Immediate/diagnosis ; Hypersensitivity, Immediate/immunology ; Proteins/immunology ; Skin Tests
    • Abstract:
      Occupational contact dermatitis is generally caused by haptens but can also be induced by proteins causing mainly immunological contact urticaria (ICU); chronic hand eczema in the context of protein contact dermatitis (PCD). In a monocentric retrospective study, from our database, only 31 (0.41%) of patients with contact dermatitis had positive skin tests with proteins: 22 had occupational PCD, 3 had non-occupational PCD, 5 occupational ICU and 1 cook had a neutrophilic fixed food eruption (NFFE) due to fish. From these results and analysis of literature, the characteristics of PCD can be summarized as follows. It is a chronic eczematous dermatitis, possibly exacerbated by work, suggestive if associated with inflammatory perionyxix and immediate erythema with pruritis, to be investigated when the patient resumes work after a period of interruption. Prick tests with the suspected protein-containing material are essential, as patch tests have negative results. In case of multisensitisation revealed by prick tests, it is advisable to analyse IgE against recombinant allergens. A history of atopy, found in 56 to 68% of the patients, has to be checked for. Most of the cases are observed among food-handlers but PCD can also be due to non-edible plants, latex, hydrolysed proteins or animal proteins. Occupational exposure to proteins can thus lead to the development of ICU. Reflecting hypersensitivity to very low concentrations of allergens, investigating ICU therefore requires caution and prick tests should be performed with a diluted form of the causative protein-containing product. Causes are food, especially fruit peel, non-edible plants, cosmetic products, latex, animals.
    • Contributed Indexing:
      Keywords: chronic hand eczema; immunological contact urticaria; neutrophilic fixed food eruption; prick test; protein allergy; protein contact dermatitis
    • Accession Number:
      0 (Proteins)
    • Publication Date:
      Date Created: 20150806 Date Completed: 20161101 Latest Revision: 20161230
    • Publication Date:
      20240829
    • Accession Number:
      10.1684/ejd.2015.2593
    • Accession Number:
      26242922