Glutamic acid decarboxylase autoantibodies are dominant but insufficient to identify most Chinese with adult-onset non-insulin requiring autoimmune diabetes: LADA China study 5.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9200299 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-5233 (Electronic) Linking ISSN: 09405429 NLM ISO Abbreviation: Acta Diabetol Subsets: MEDLINE
    • Publication Information:
      Publication: Berlin : Springer Verlag
      Original Publication: Berlin : Springer International, c1991-
    • Subject Terms:
      Autoantibodies/*analysis ; Diabetes Mellitus, Type 2/*diagnosis ; Glutamate Decarboxylase/*immunology; Adult ; Aged ; Asian People ; Biomarkers ; Cation Transport Proteins/immunology ; China ; Female ; Humans ; Islets of Langerhans/immunology ; Male ; Middle Aged ; Prevalence ; Protein Phosphatase 2/immunology ; Zinc Transporter 8
    • Abstract:
      Aims: Adult-onset autoimmune diabetes is prevalent in China, in contrast to childhood-onset type 1 diabetes mellitus. Islet autoantibodies are the most important immune biomarkers to diagnose autoimmune diabetes. We assayed four different islet autoantibodies in recently diagnosed adult non-insulin-requiring diabetes Chinese subjects to investigate the best antibody assay strategy for the correct diagnosis of these subjects.
      Methods: LADA China study is a nation-wide multicenter study conducted in diabetes patients from 46 university-affiliated hospitals in China. Non-insulin-treated newly diagnosed adult diabetes patients (n = 2388) were centrally assayed for glutamic acid decarboxylase autoantibody (GADA), protein tyrosine phosphatase-2 autoantibody (IA-2A), and zinc transporter 8 autoantibody (ZnT8A) by radioligand assay and insulin autoantibody (IAA) by microtiter plate radioimmunoassay. Clinical data were determined locally.
      Results: Two hundred and six (8.63 %) subjects were autoantibody positive, of which GADA identified 5.78 % (138/2388) of the total, but only 67 % (138/206) of the autoimmune cases. IA-2A, ZnT8A, and IAA were found in 1.51, 1.84, and 1.26 % of the total study subjects, respectively. When assaying three islet autoantibodies, the most effective strategy was the combination of GADA, ZnT8A, and IAA, which could identify 92.2 % (190/206) autoimmune diabetes patients. The clinical data showed that those subjects with positive GADA had lower random C-peptide than autoantibody negative subjects (P < 0.05).
      Conclusions: As with Europeans, GADA is the dominant autoantibody in this form of autoimmune diabetes in China, but in contrast to Europeans, screening should include other diabetes-associated autoantibodies.
    • References:
      Br Med J. 1976 Jun 26;1(6025):1565-7. (PMID: 776343)
      Chin Med J (Engl). 2003 Nov;116(11):1728-32. (PMID: 14642146)
      Proc Natl Acad Sci U S A. 1986 Nov;83(22):8808-12. (PMID: 2430303)
      Diabetes. 2005 Jan;54(1):166-74. (PMID: 15616025)
      World J Gastroenterol. 2005 May 21;11(19):2900-5. (PMID: 15902725)
      Diabetologia. 2005 Nov;48(11):2206-12. (PMID: 16193284)
      Diabetologia. 2007 Oct;50(10):2052-60. (PMID: 17657474)
      Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17040-5. (PMID: 17942684)
      Diabetes Care. 2010 Jan;33(1):104-8. (PMID: 19808923)
      Diabetes. 2010 Feb;59(2):416-22. (PMID: 19864397)
      Diabetes Metab Res Rev. 2010 Oct;26(7):579-84. (PMID: 20842762)
      Diabetes. 2012 Mar;61(3):683-6. (PMID: 22315309)
      Front Med. 2012 Sep;6(3):243-7. (PMID: 22843304)
      Acta Diabetol. 2012 Oct;49(5):327-31. (PMID: 20473693)
      Diabetes. 2013 Feb;62(2):543-50. (PMID: 23086039)
      Diabetes Care. 2013 Apr;36(4):908-13. (PMID: 23248199)
      Acta Diabetol. 2013 Apr;50(2):129-34. (PMID: 20953640)
      J Diabetes. 2013 Jun;5(2):118-26. (PMID: 23448619)
      Diabetes Metab Res Rev. 2013 Jul;29(5):363-8. (PMID: 23390067)
      Acta Diabetol. 2014 Oct;51(5):691-703. (PMID: 25005490)
      Diabetes Metab Res Rev. 2000 Nov-Dec;16(6):442-47. (PMID: 11114103)
      Chin Med J (Engl). 1999 Jun;112(6):554-7. (PMID: 11601338)
      Science. 1983 Dec 23;222(4630):1337-9. (PMID: 6362005)
    • Contributed Indexing:
      Keywords: Glutamic acid decarboxylase antibody (GADA); Insulin autoantibody (IAA); Latent autoimmune diabetes of adults (LADA); Protein tyrosine phosphatase-2 antibody (IA-2A); Zinc transporter 8 autoantibody (ZnT8A)
    • Accession Number:
      0 (Autoantibodies)
      0 (Biomarkers)
      0 (Cation Transport Proteins)
      0 (SLC30A8 protein, human)
      0 (Zinc Transporter 8)
      EC 3.1.3.16 (Protein Phosphatase 2)
      EC 4.1.1.15 (Glutamate Decarboxylase)
    • Publication Date:
      Date Created: 20150805 Date Completed: 20161213 Latest Revision: 20221207
    • Publication Date:
      20240628
    • Accession Number:
      PMC4628082
    • Accession Number:
      10.1007/s00592-015-0799-8
    • Accession Number:
      26239144