Menu
×
Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. – 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. – 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. – 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. – 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. - 4 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. – 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. – 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. – 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. – 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. – 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Today's Hours
Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. – 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. – 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. – 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. – 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. - 4 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. – 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. – 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. – 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. – 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. – 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Patron Login
menu
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Glutamic acid decarboxylase autoantibodies are dominant but insufficient to identify most Chinese with adult-onset non-insulin requiring autoimmune diabetes: LADA China study 5.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Xiang Y;Xiang Y; Huang G; Huang G; Shan Z; Shan Z; Pan L; Pan L; Luo S; Luo S; Yang L; Yang L; Shi L; Shi L; Li Q; Li Q; Leslie RD; Leslie RD; Zhou Z; Zhou Z
- Source:
Acta diabetologica [Acta Diabetol] 2015 Dec; Vol. 52 (6), pp. 1121-7. Date of Electronic Publication: 2015 Aug 05.- Publication Type:
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9200299 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-5233 (Electronic) Linking ISSN: 09405429 NLM ISO Abbreviation: Acta Diabetol Subsets: MEDLINE
- Publication Information: Publication: Berlin : Springer Verlag
Original Publication: Berlin : Springer International, c1991- - Subject Terms: Autoantibodies/*analysis ; Diabetes Mellitus, Type 2/*diagnosis ; Glutamate Decarboxylase/*immunology; Adult ; Aged ; Asian People ; Biomarkers ; Cation Transport Proteins/immunology ; China ; Female ; Humans ; Islets of Langerhans/immunology ; Male ; Middle Aged ; Prevalence ; Protein Phosphatase 2/immunology ; Zinc Transporter 8
- Abstract: Aims: Adult-onset autoimmune diabetes is prevalent in China, in contrast to childhood-onset type 1 diabetes mellitus. Islet autoantibodies are the most important immune biomarkers to diagnose autoimmune diabetes. We assayed four different islet autoantibodies in recently diagnosed adult non-insulin-requiring diabetes Chinese subjects to investigate the best antibody assay strategy for the correct diagnosis of these subjects.
Methods: LADA China study is a nation-wide multicenter study conducted in diabetes patients from 46 university-affiliated hospitals in China. Non-insulin-treated newly diagnosed adult diabetes patients (n = 2388) were centrally assayed for glutamic acid decarboxylase autoantibody (GADA), protein tyrosine phosphatase-2 autoantibody (IA-2A), and zinc transporter 8 autoantibody (ZnT8A) by radioligand assay and insulin autoantibody (IAA) by microtiter plate radioimmunoassay. Clinical data were determined locally.
Results: Two hundred and six (8.63 %) subjects were autoantibody positive, of which GADA identified 5.78 % (138/2388) of the total, but only 67 % (138/206) of the autoimmune cases. IA-2A, ZnT8A, and IAA were found in 1.51, 1.84, and 1.26 % of the total study subjects, respectively. When assaying three islet autoantibodies, the most effective strategy was the combination of GADA, ZnT8A, and IAA, which could identify 92.2 % (190/206) autoimmune diabetes patients. The clinical data showed that those subjects with positive GADA had lower random C-peptide than autoantibody negative subjects (P < 0.05).
Conclusions: As with Europeans, GADA is the dominant autoantibody in this form of autoimmune diabetes in China, but in contrast to Europeans, screening should include other diabetes-associated autoantibodies. - References: Br Med J. 1976 Jun 26;1(6025):1565-7. (PMID: 776343)
Chin Med J (Engl). 2003 Nov;116(11):1728-32. (PMID: 14642146)
Proc Natl Acad Sci U S A. 1986 Nov;83(22):8808-12. (PMID: 2430303)
Diabetes. 2005 Jan;54(1):166-74. (PMID: 15616025)
World J Gastroenterol. 2005 May 21;11(19):2900-5. (PMID: 15902725)
Diabetologia. 2005 Nov;48(11):2206-12. (PMID: 16193284)
Diabetologia. 2007 Oct;50(10):2052-60. (PMID: 17657474)
Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17040-5. (PMID: 17942684)
Diabetes Care. 2010 Jan;33(1):104-8. (PMID: 19808923)
Diabetes. 2010 Feb;59(2):416-22. (PMID: 19864397)
Diabetes Metab Res Rev. 2010 Oct;26(7):579-84. (PMID: 20842762)
Diabetes. 2012 Mar;61(3):683-6. (PMID: 22315309)
Front Med. 2012 Sep;6(3):243-7. (PMID: 22843304)
Acta Diabetol. 2012 Oct;49(5):327-31. (PMID: 20473693)
Diabetes. 2013 Feb;62(2):543-50. (PMID: 23086039)
Diabetes Care. 2013 Apr;36(4):908-13. (PMID: 23248199)
Acta Diabetol. 2013 Apr;50(2):129-34. (PMID: 20953640)
J Diabetes. 2013 Jun;5(2):118-26. (PMID: 23448619)
Diabetes Metab Res Rev. 2013 Jul;29(5):363-8. (PMID: 23390067)
Acta Diabetol. 2014 Oct;51(5):691-703. (PMID: 25005490)
Diabetes Metab Res Rev. 2000 Nov-Dec;16(6):442-47. (PMID: 11114103)
Chin Med J (Engl). 1999 Jun;112(6):554-7. (PMID: 11601338)
Science. 1983 Dec 23;222(4630):1337-9. (PMID: 6362005) - Contributed Indexing: Keywords: Glutamic acid decarboxylase antibody (GADA); Insulin autoantibody (IAA); Latent autoimmune diabetes of adults (LADA); Protein tyrosine phosphatase-2 antibody (IA-2A); Zinc transporter 8 autoantibody (ZnT8A)
- Accession Number: 0 (Autoantibodies)
0 (Biomarkers)
0 (Cation Transport Proteins)
0 (SLC30A8 protein, human)
0 (Zinc Transporter 8)
EC 3.1.3.16 (Protein Phosphatase 2)
EC 4.1.1.15 (Glutamate Decarboxylase) - Publication Date: Date Created: 20150805 Date Completed: 20161213 Latest Revision: 20221207
- Publication Date: 20240628
- Accession Number: PMC4628082
- Accession Number: 10.1007/s00592-015-0799-8
- Accession Number: 26239144
- Source:
Contact CCPL
Copyright 2022 Charleston County Public Library Powered By EBSCO Stacks 3.3.0 [350.3] | Staff Login
No Comments.