Asthma Is More Severe in Older Adults.

Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Original Publication: San Francisco, CA : Public Library of Science

Aging* ; Severity of Illness Index*; Asthma/*pathology ; Asthma/*physiopathology; Adolescent ; Adult ; Age Factors ; Aged ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies

Background: Severe asthma occurs more often in older adult patients. We hypothesized that the greater risk for severe asthma in older individuals is due to aging, and is independent of asthma duration.
Methods: This is a cross-sectional study of prospectively collected data from adult participants (N=1130; 454 with severe asthma) enrolled from 2002 - 2011 in the Severe Asthma Research Program.
Results: The association between age and the probability of severe asthma, which was performed by applying a Locally Weighted Scatterplot Smoother, revealed an inflection point at age 45 for risk of severe asthma. The probability of severe asthma increased with each year of life until 45 years and thereafter increased at a much slower rate. Asthma duration also increased the probability of severe asthma but had less effect than aging. After adjustment for most comorbidities of aging and for asthma duration using logistic regression, asthmatics older than 45 maintained the greater probability of severe asthma [OR: 2.73 (95 CI: 1.96; 3.81)]. After 45, the age-related risk of severe asthma continued to increase in men, but not in women.
Conclusions: Overall, the impact of age and asthma duration on risk for asthma severity in men and women is greatest over times of 18-45 years of age; age has a greater effect than asthma duration on risk of severe asthma.

J Allergy Clin Immunol. 2003 Jun;111(6):1212-8. (PMID: 12789219)
Eur Respir J. 2002 Sep;20(3):763-76. (PMID: 12358357)
Ann Allergy Asthma Immunol. 2003 Dec;91(6):553-8. (PMID: 14700439)
Allergy. 2004 May;59(5):469-78. (PMID: 15080825)
Aging Cell. 2004 Aug;3(4):217-26. (PMID: 15268755)
Science. 2004 Sep 17;305(5691):1776-9. (PMID: 15375268)
Respir Physiol. 1969 Dec;8(1):58-65. (PMID: 5366416)
J Appl Physiol. 1972 Apr;32(4):483-5. (PMID: 5026496)
J Appl Physiol. 1974 Apr;36(4):412-8. (PMID: 4820322)
Am Rev Respir Dis. 1980 Oct;122(4):567-75. (PMID: 7436122)
Am J Med. 1984 Jul;77(1):64-71. (PMID: 6741986)
Clin Geriatr Med. 1985 Feb;1(1):143-75. (PMID: 3913497)
Eur J Respir Dis. 1987 Mar;70(3):171-9. (PMID: 3569449)
Chest. 1992 Mar;101(3):793-9. (PMID: 1541148)
Thorax. 1992 Feb;47(2):76-83. (PMID: 1549827)
Am J Respir Crit Care Med. 1994 Sep;150(3):629-34. (PMID: 8087330)
Pediatr Pulmonol. 1995 Mar;19(3):161-6. (PMID: 7792118)
Biometrics. 1995 Jun;51(2):600-14. (PMID: 7662848)
Am J Respir Crit Care Med. 1995 Oct;152(4 Pt 1):1183-8. (PMID: 7551368)
Stat Med. 1996 Feb 28;15(4):361-87. (PMID: 8668867)
Eur Respir J. 1997 Aug;10(8):1780-6. (PMID: 9272919)
N Engl J Med. 1998 Oct 22;339(17):1194-200. (PMID: 9780339)
Mech Ageing Dev. 1998 Aug 14;104(2):169-81. (PMID: 9792195)
Eur Respir J. 1998 Dec;12(6):1322-6. (PMID: 9877485)
Am J Respir Crit Care Med. 2005 Jul 1;172(1):45-54. (PMID: 15805179)
Thorax. 2006 Jan;61(1):34-40. (PMID: 16244093)
Thorax. 2006 Feb;61(2):105-10. (PMID: 16308336)
Clin Exp Allergy. 2006 May;36(5):609-13. (PMID: 16650045)
Eur J Appl Physiol. 2007 Apr;99(6):567-83. (PMID: 17237952)
Respir Med. 2007 Nov;101(11):2370-7. (PMID: 17689949)
Allergy. 2008 Jan;63(1):47-57. (PMID: 17822448)
J Allergy Clin Immunol. 2008 Jan;121(1):72-80.e3. (PMID: 18028993)
Am J Respir Crit Care Med. 2008 Aug 1;178(3):218-24. (PMID: 18480428)
Pediatr Res. 2009 Jan;65(1):117-22. (PMID: 18787504)
Am J Respir Crit Care Med. 2010 Feb 15;181(4):315-23. (PMID: 19892860)
N Engl J Med. 2011 May 26;364(21):2006-15. (PMID: 21612469)
Am J Respir Crit Care Med. 2012 Feb 15;185(4):356-62. (PMID: 22095547)
NCHS Data Brief. 2012 May;(94):1-8. (PMID: 22617340)
Thorax. 2012 Jul;67(7):625-31. (PMID: 22334535)
Chest. 2013 Apr;143(4):984-92. (PMID: 23632943)
Eur Respir J. 2013 Jun;41(6):1308-14. (PMID: 23060627)
Eur Respir J. 2014 Feb;43(2):343-73. (PMID: 24337046)
Am J Respir Crit Care Med. 2000 Dec;162(6):2341-51. (PMID: 11112161)
Eur Respir J. 1999 Jan;13(1):197-205. (PMID: 10836348)
Nat Commun. 2014;2:4172. (PMID: 24960204)
Thorax. 2001 Aug;56(8):613-6. (PMID: 11462063)
Eur Respir J. 2002 Jan;19(1):61-7. (PMID: 11843329)
Am J Respir Crit Care Med. 2002 Jul 15;166(2):166-72. (PMID: 12119228)
Eur Respir J. 2003 Sep;22(3):470-7. (PMID: 14516137)

U10 HL109257 United States HL NHLBI NIH HHS; P01 HL081064 United States HL NHLBI NIH HHS; R01 HL069170 United States HL NHLBI NIH HHS; HL081064 United States HL NHLBI NIH HHS; U10 HL109250 United States HL NHLBI NIH HHS; P01 HL103453 United States HL NHLBI NIH HHS; UL1TR000439 United States TR NCATS NIH HHS; U10 HL109172 United States HL NHLBI NIH HHS; HL69170 United States HL NHLBI NIH HHS; UL1 TR000427 United States TR NCATS NIH HHS; UL1 TR000439 United States TR NCATS NIH HHS; HL103453 United States HL NHLBI NIH HHS; U10 HL109152 United States HL NHLBI NIH HHS; HL109250 United States HL NHLBI NIH HHS

Date Created: 20150723 Date Completed: 20160429 Latest Revision: 20201215

20231215

PMC4511639

10.1371/journal.pone.0133490

26200463