The TNF-family cytokine TL1A: from lymphocyte costimulator to disease co-conspirator.

Publisher: Oxford University Press Country of Publication: England NLM ID: 8405628 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-3673 (Electronic) Linking ISSN: 07415400 NLM ISO Abbreviation: J Leukoc Biol Subsets: MEDLINE

Publication: 2023- : Oxford : Oxford University Press
Original Publication: New York : Alan R. Liss, c1984-

Autoimmune Diseases/*immunology ; Receptors, Death Domain/*metabolism ; Tumor Necrosis Factor Ligand Superfamily Member 15/*metabolism; Animals ; Autoimmune Diseases/pathology ; Disease Models, Animal ; Humans ; Lymphocyte Activation/immunology ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology

Originally described in 2002 as a T cell-costimulatory cytokine, the tumor necrosis factor family member TNF-like factor 1A (TL1A), encoded by the TNFSF15 gene, has since been found to affect multiple cell lineages through its receptor, death receptor 3 (DR3, encoded by TNFRSF25) with distinct cell-type effects. Genetic deficiency or blockade of TL1A-DR3 has defined a number of disease states that depend on this cytokine-receptor pair, whereas excess TL1A leads to allergic gastrointestinal inflammation through stimulation of group 2 innate lymphoid cells. Noncoding variants in the TL1A locus are associated with susceptibility to inflammatory bowel disease and leprosy, predicting that the level of TL1A expression may influence host defense and the development of autoimmune and inflammatory diseases.
(© Society for Leukocyte Biology.)

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United States Intramural NIH HHS

Keywords: DR3; autoimmune disease

0 (Receptors, Death Domain)
0 (Tumor Necrosis Factor Ligand Superfamily Member 15)

Date Created: 20150719 Date Completed: 20151123 Latest Revision: 20240524

20240524

PMC4763597

10.1189/jlb.3RI0315-095R

26188076