Timing of post-exercise carbohydrate ingestion: influence on IL-6 and hepcidin responses.

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  • Additional Information
    • Source:
      Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 100954790 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-6327 (Electronic) Linking ISSN: 14396319 NLM ISO Abbreviation: Eur J Appl Physiol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Berlin ; New York : Springer-Verlag, c2000-
    • Subject Terms:
      Exercise*; Dietary Carbohydrates/*pharmacology ; Hepcidins/*blood ; Interleukin-6/*blood; Adolescent ; Adult ; Dietary Carbohydrates/administration & dosage ; Drug Administration Schedule ; Eating ; Humans ; Iron/blood ; Male ; Physical Endurance/drug effects
    • Abstract:
      Purpose: Carbohydrate ingestion prior and during exercise attenuates exercise-induced interleukin-6. This investigation examined if an analogous effect was evident for interleukin-6 and hepcidin response when carbohydrates were ingested post-exercise.
      Methods: In a crossover design, 11 well-trained endurance athletes completed two experimental trials. Participants completed an 8 × 3 min interval running session at 85 % vVO2peak followed by 5 h of monitored recovery. During this period, participants were provided with two 1.2 g kg(-1) carbohydrate beverages at either an early feeding time (immediately post-exercise and 2 h post-exercise) or delayed feeding time (2 h post-exercise and 4 h post-exercise). Venous blood samples were collected pre-, immediately post-, 3 and 5 h post-exercise. Samples were analysed for Interleukin-6, serum iron, serum ferritin and hepcidin.
      Results: Interleukin-6 was significantly elevated (p = 0.004) immediately post-exercise compared to baseline for both trials. Hepcidin levels were significantly elevated at 3 h post-exercise (p = 0.001) and 5 h post-exercise (p = 0.002) compared to baseline levels in both trials, with no significant difference between the two conditions and any time point. Serum iron was significantly increased from baseline to immediately post-exercise (p = 0.001) for both trials, with levels decreasing by 3 h (p = 0.025) and 5 h post-exercise (p = 0.001). Serum ferritin levels increased immediately post-exercise compared to baseline (p = 0.006) in both conditions.
      Conclusions: The timing and ingestion of post-exercise carbohydrate ingestion do not appear to impact post-exercise interleukin-6 and hepcidin responses; this is likely a result of the interval running task inducing an inflammatory response and subsequent up-regulation of hepcidin.
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    • Contributed Indexing:
      Keywords: Cytokine; Interval running; Iron metabolism; Nutrition
    • Accession Number:
      0 (Dietary Carbohydrates)
      0 (Hepcidins)
      0 (Interleukin-6)
      E1UOL152H7 (Iron)
    • Publication Date:
      Date Created: 20150619 Date Completed: 20160617 Latest Revision: 20181113
    • Publication Date:
      20231215
    • Accession Number:
      10.1007/s00421-015-3202-0
    • Accession Number:
      26084589