Ceftriaxone attenuates acquisition and facilitates extinction of cocaine-induced suppression of saccharin intake in C57BL/6J mice.

Publisher: Elsevier Science Country of Publication: United States NLM ID: 0151504 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-507X (Electronic) Linking ISSN: 00319384 NLM ISO Abbreviation: Physiol Behav Subsets: MEDLINE

Publication: New York NY : Elsevier Science
Original Publication: Oxford, Eng., Long Island City, Pergamon Press.

Anti-Bacterial Agents/*pharmacology ; Ceftriaxone/*pharmacology ; Cocaine/*pharmacology ; Dopamine Uptake Inhibitors/*pharmacology ; Extinction, Psychological/*drug effects ; Food Preferences/*drug effects ; Saccharin/*administration & dosage ; Sweetening Agents/*administration & dosage; Animals ; Conditioning, Operant/drug effects ; Drug Interactions ; Individuality ; Inhibition, Psychological ; Male ; Mice ; Mice, Inbred C57BL ; Self Administration ; Statistics, Nonparametric ; Taste/drug effects

Growing evidence implicates glutamate homeostasis in a number of behaviors observed in addiction such as acquisition of drug taking, motivation, and reinstatement. To date, however, the role of glutamate homeostasis in the avoidance of natural rewards due to exposure to drugs of abuse has received little attention. The aim of the current study was to evaluate the beta-lactam antibiotic, ceftriaxone, which has been shown to normalize disrupted glutamate homeostasis associated with exposure to drugs of abuse, in cocaine-induced suppression of saccharin intake in C57BL/6J mice. Briefly, C57BL/6J mice received daily injections of either 200mg/kg ceftriaxone or saline. Mice were then given access to 0.15% saccharin for 1h and immediately injected intraperitoneally with either saline or 30 mg/kg cocaine; taste-drug pairings occurred every 24h for 5 trials followed by a final CS only trial. One week following taste-drug pairings, extinction was evaluated in a series of one- and two-bottle saccharin intake tests. Individual differences in cocaine-induced suppression were observed (i.e., low and high suppressors) with differential effects of ceftriaxone. Ceftriaxone delayed suppression of saccharin intake in high suppressors but prevented suppression in low suppressors. In addition, ceftriaxone history facilitated extinction in the high suppressors. These data suggest that changes in glutamate homeostasis may be involved in the formation and expression of cocaine-induced suppression of saccharin intake in mice.
(Copyright © 2015. Published by Elsevier Inc.)

Psychopharmacologia. 1973;29(3):239-46. (PMID: 4702275)
Neuron. 1996 Mar;16(3):675-86. (PMID: 8785064)
Pharmacol Biochem Behav. 1978 Jun;8(6):757-61. (PMID: 693561)
Neuropharmacology. 2013 Dec;75:213-22. (PMID: 23973312)
Neurosci Lett. 2014 Feb 7;560:98-102. (PMID: 24370597)
Physiol Behav. 2015 Feb;139:216-23. (PMID: 25449401)
Behav Brain Res. 2003 May 15;141(2):177-82. (PMID: 12742254)
Nat Neurosci. 2003 Jul;6(7):743-9. (PMID: 12778052)
J Biol Chem. 1986 Feb 15;261(5):2256-63. (PMID: 2868011)
Brain Res. 2000 Apr 28;863(1-2):52-8. (PMID: 10773192)
J Neurosci. 2002 Oct 15;22(20):9134-41. (PMID: 12388621)
Behav Brain Res. 2014 Jul 1;267:1-5. (PMID: 24613241)
Restor Neurol Neurosci. 2013;31(1):87-97. (PMID: 23047495)
Behav Brain Res. 2011 Nov 20;225(1):252-8. (PMID: 21824497)
Behav Neurosci. 2009 Apr;123(2):397-407. (PMID: 19331462)
J Neurosci. 2012 Sep 5;32(36):12406-10. (PMID: 22956831)
Front Behav Neurosci. 2014 May 07;8:153. (PMID: 24847227)
Behav Neurosci. 1997 Feb;111(1):129-36. (PMID: 9109631)
Neurosci Lett. 2013 Nov 27;556:155-9. (PMID: 24120434)
Behav Neurosci. 2002 Apr;116(2):321-33. (PMID: 11996317)
Behav Neurosci. 2013 Jun;127(3):474-84. (PMID: 23544599)
Behav Brain Res. 2005 Jan 30;156(2):233-9. (PMID: 15582109)
Neurobiol Learn Mem. 2009 Oct;92(3):460-3. (PMID: 19439188)
Pharmacol Rev. 2012 Jul;64(3):780-802. (PMID: 22759795)
J Biol Chem. 1980 Mar 25;255(6):2372-6. (PMID: 7358676)
J Neural Transm (Vienna). 2014 Aug;121(8):799-817. (PMID: 24578174)
Behav Pharmacol. 2011 Aug;22(4):370-3. (PMID: 21543969)
Nature. 2001 May 31;411(6837):583-7. (PMID: 11385572)
Eur J Neurosci. 2005 Dec;22(11):2744-54. (PMID: 16324108)
J Neurosci. 2009 Jul 22;29(29):9239-43. (PMID: 19625514)
J Exp Psychol Anim Behav Process. 1976 Jan;2(1):17-27. (PMID: 1249524)
Pharmacol Biochem Behav. 2013 Jul;108:61-5. (PMID: 23628489)
Brain Res. 1995 Jun 19;683(2):264-9. (PMID: 7552364)
Pharmacol Biochem Behav. 2014 Jul;122:118-21. (PMID: 24650590)
Chem Senses. 2014 Mar;39(3):203-13. (PMID: 24363269)
Behav Neurosci. 2007 Dec;121(6):1234-42. (PMID: 18085877)
J Neurosci. 2013 Nov 6;33(45):17641-6. (PMID: 24198356)
Biol Psychiatry. 2010 Jan 1;67(1):81-4. (PMID: 19717140)
Pharmacol Biochem Behav. 1974 May;2(3):325-30. (PMID: 4837904)
J Neurochem. 1984 Nov;43(5):1438-46. (PMID: 6149260)
Psychopharmacology (Berl). 2013 Mar;226(1):167-76. (PMID: 23104263)

R01 DA009815 United States DA NIDA NIH HHS; R37 DA009815 United States DA NIDA NIH HHS; DA009815 United States DA NIDA NIH HHS

Keywords: Addiction; Glia; Glutamate; Natural rewards; Reward comparison

0 (Anti-Bacterial Agents)
0 (Dopamine Uptake Inhibitors)
0 (Sweetening Agents)
75J73V1629 (Ceftriaxone)
FST467XS7D (Saccharin)
I5Y540LHVR (Cocaine)

Date Created: 20150613 Date Completed: 20160411 Latest Revision: 20191210

20240829

PMC4506918

10.1016/j.physbeh.2015.06.009

26066719