[Thrombin generation test].

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  • Author(s): Espitia O;Espitia O; Fouassier M; Fouassier M
  • Source:
    La Revue de medecine interne [Rev Med Interne] 2015 Oct; Vol. 36 (10), pp. 690-3. Date of Electronic Publication: 2015 May 28.
  • Publication Type:
    English Abstract; Journal Article
  • Language:
    French
  • Additional Information
    • Transliterated Title:
      Le test de génération de thrombine.
    • Source:
      Publisher: Elsevier Country of Publication: France NLM ID: 8101383 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3122 (Electronic) Linking ISSN: 02488663 NLM ISO Abbreviation: Rev Med Interne Subsets: MEDLINE
    • Publication Information:
      Publication: Paris : Elsevier
      Original Publication: Paris : Baillière, [1980-
    • Subject Terms:
      Blood Coagulation Tests/*methods ; Thrombin/*metabolism; Anticoagulants/therapeutic use ; Antiphospholipid Syndrome/blood ; Blood Coagulation Tests/classification ; Blood Coagulation Tests/standards ; Hemorrhage/blood ; Hemorrhage/prevention & control ; Hemostasis/physiology ; Humans ; Neoplasms/blood ; Neoplasms/pathology ; Product Surveillance, Postmarketing/methods ; Reference Values ; Thrombophilia/blood ; Thrombophilia/diagnosis ; Venous Thromboembolism/blood ; Venous Thromboembolism/diagnosis
    • Abstract:
      Thrombin is a key enzyme of the coagulation cascade, having both pro- and anticoagulant functions. Global haemostasis assay, the so-called thrombin generation test is appropriate for its assessment. Estimation of an individual's potential to generate thrombin may correlate more closely with a hyper- or hypo-coagulable phenotype, compared to traditional coagulation tests. In patients at risk of venous thrombosis, thrombin generation analysis may be utilized to detect underlying thrombophilia. In patients with documented venous thromboembolism, increased thrombin generation values are seen in those patients at greatest risk for recurrence. In patients with arterial vascular disease, the data are limited. In case of haemophilia thrombin generation assays reflect bleeding severity. It is applicable for monitoring of both conventional haemophilia treatment and inhibitor-bypassing therapy, which is needed when inhibitors develop in patients. Standardization of thrombin generation methods and determination of cut off-values are required before its application in clinical practice.
      (Copyright © 2015 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.)
    • Contributed Indexing:
      Keywords: Haemophilia; Hémophilie; Test de génération de thrombine; Thrombin generation test; Thrombose veineuse; Venous thromboembolism
    • Accession Number:
      0 (Anticoagulants)
      EC 3.4.21.5 (Thrombin)
    • Publication Date:
      Date Created: 20150602 Date Completed: 20160629 Latest Revision: 20161018
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.revmed.2015.04.013
    • Accession Number:
      26028157