Environmental Enrichment Improves Behavior, Cognition, and Brain Functional Markers in Young Senescence-Accelerated Prone Mice (SAMP8).

Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

Original Publication: Clifton, NJ : Humana Press, c1987-

Behavior, Animal* ; Cognition* ; Environment*; Aging/*physiology ; Biomarkers/*metabolism ; Brain/*physiology; Amyloid beta-Protein Precursor/metabolism ; Animals ; Blotting, Western ; Caspase 3/metabolism ; Enzyme Activation ; Epigenesis, Genetic ; Glial Fibrillary Acidic Protein/metabolism ; Hippocampus/metabolism ; Inflammation/pathology ; Male ; Mice, Transgenic ; Motivation ; Neurons/metabolism ; Protein Kinases/metabolism ; Protein Processing, Post-Translational ; Spatial Memory

The environment in which organisms live can greatly influence their development. Consequently, environmental enrichment (EE) is progressively recognized as an important component in the improvement of brain function and development. It has been demonstrated that rodents raised under EE conditions exhibit favorable neuroanatomical effects that improve their learning, spatial memory, and behavioral performance. Here, by using senescence-accelerated prone mice (SAMP8) and these as a model of adverse genetic conditions for brain development, we determined the effect of EE by raising these mice during early life under favorable conditions. We found a better generalized performance of SAMP8 under EE in the results of four behavioral and learning tests. In addition, we demonstrated broad molecular correlation in the hippocampus by an increase in NeuN and Ki67 expression, as well as an increase in the expression of neurotrophic factors, such as pleiotrophin (PTN) and brain-derived neurotrophic factor (BDNF), with a parallel decrease in neurodegenerative markers such as GSK3, amyloid-beta precursor protein, and phosphorylated beta-catenin, and a reduction of SBDP120, Bax, GFAP, and interleukin-6 (IL-6), resulting in a neuroprotective panorama. Globally, it can be concluded that EE applied to SAMP8 at young ages resulted in epigenetic regulatory mechanisms that give rise to significant beneficial effects at the molecular, cellular, and behavioral levels during brain development, particularly in the hippocampus.

Curr Pharm Des. 2012;18(8):1123-30. (PMID: 22288401)
J Comp Physiol Psychol. 1962 Oct;55:801-7. (PMID: 14035653)
Behav Brain Res. 1988 Nov 1;31(1):47-59. (PMID: 3228475)
Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12880-4. (PMID: 11070096)
Neurochem Res. 2009 Apr;34(4):639-59. (PMID: 19199030)
Neurobiol Learn Mem. 2011 Jul;96(1):13-8. (PMID: 21320618)
Neuron. 2007 Mar 15;53(6):857-69. (PMID: 17359920)
Neuroscience. 2014 Sep 26;277:103-10. (PMID: 25010400)
J Cell Sci. 2001 Apr;114(Pt 7):1251. (PMID: 11256991)
Eur J Neurosci. 2005 Jan;21(2):513-21. (PMID: 15673450)
Neurobiol Aging. 1999 Mar-Apr;20(2):111-5. (PMID: 10537020)
PLoS One. 2013 May 21;8(5):e64460. (PMID: 23700479)
Learn Mem. 2014 Jun 17;21(7):351-62. (PMID: 24939839)
Prog Neurobiol. 2010 Dec;92(4):572-92. (PMID: 20713127)
Ment Retard Dev Disabil Res Rev. 2004;10(4):248-58. (PMID: 15666335)
Nat Rev Neurosci. 2000 Dec;1(3):191-8. (PMID: 11257907)
J Alzheimers Dis. 2008 Dec;15(4):615-24. (PMID: 19096160)
Apoptosis. 2009 Nov;14(11):1289-98. (PMID: 19771521)
Ageing Res Rev. 2014 Jan;13:13-37. (PMID: 24269312)
Exp Neurol. 2010 Jun;223(2):267-81. (PMID: 19699201)
Neurobiol Dis. 2008 Aug;31(2):159-68. (PMID: 18585920)
Neural Regen Res. 2012 Aug 15;7(23):1797-804. (PMID: 25624804)
Nat Rev Neurosci. 2006 Sep;7(9):697-709. (PMID: 16924259)
J Pineal Res. 2012 Apr;52(3):271-81. (PMID: 22085194)
J Cell Physiol. 2000 Mar;182(3):311-22. (PMID: 10653597)
J Pineal Res. 2008 Nov;45(4):497-505. (PMID: 18705649)
J Neuroinflammation. 2014 Jul 23;11:126. (PMID: 25051986)
Mech Ageing Dev. 2005 Dec;126(12 ):1300-4. (PMID: 16171847)
Front Cell Neurosci. 2015 Jan 08;8:443. (PMID: 25620911)
Nat Protoc. 2006;1(2):848-58. (PMID: 17406317)
Prog Brain Res. 2002;138:109-33. (PMID: 12432766)
Neurobiol Learn Mem. 2011 Jul;96(1):2-12. (PMID: 21195202)
Lab Anim Sci. 1991 Aug;41(4):372-7. (PMID: 1658487)
Biochim Biophys Acta. 2012 May;1822(5):650-6. (PMID: 22142563)
Front Cell Neurosci. 2014 Apr 03;8:97. (PMID: 24772064)
Exp Gerontol. 2006 Apr;41(4):360-7. (PMID: 16542809)
Front Aging Neurosci. 2014 Mar 20;6:51. (PMID: 24688469)
J Alzheimers Dis. 2012;32(1):233-40. (PMID: 22776969)
Development. 1992 Sep;116(1):201-11. (PMID: 1483388)
Curr Alzheimer Res. 2005 Jan;2(1):3-18. (PMID: 15977985)
Exp Cell Res. 2004 Apr 15;295(1):245-57. (PMID: 15051507)
Behav Brain Res. 2004 Jul 9;152(2):231-41. (PMID: 15196790)
Neurobiol Learn Mem. 2008 May;89(4):599-603. (PMID: 17881251)
Pharmacol Biochem Behav. 2002 Aug;73(1):233-45. (PMID: 12076742)
Brain Res Rev. 2009 Oct;61(2):221-39. (PMID: 19631687)
Am J Physiol Regul Integr Comp Physiol. 2011 May;300(5):R1053-69. (PMID: 21346243)
Neurobiol Aging. 2007 Oct;28(10):1493-506. (PMID: 16904243)
Hippocampus. 2011 Feb;21(2):127-32. (PMID: 20232397)
Gene Ther. 2014 Jul;21(7):682-93. (PMID: 24807806)

Keywords: Aging; Apoptosis; Behavior; Cognition; Enriched environment; Hippocampus; Inflammation; Learning; Neurodenegeration; Neurogenesis; Neurotrophin; Tau kinases

0 (Amyloid beta-Protein Precursor)
0 (Biomarkers)
0 (Glial Fibrillary Acidic Protein)
EC 2.7.- (Protein Kinases)
EC 3.4.22.- (Caspase 3)

Date Created: 20150528 Date Completed: 20161226 Latest Revision: 20220310

20231215

10.1007/s12035-015-9210-6

26014386